C94.32
BillableMast cell leukemia, in relapse
HCC Category Mapping
V28HCC 20 — Lung and Other Severe Cancers
0.000V24HCC 9 — Lung and Other Severe Cancers
0.973ESRDHCC 9 — Lung and Other Severe Cancers
0.000RxHCCHCC 19 — Lymphoma and Other Cancers
0.000What This Code Means
A rare blood cancer where mast cells multiply uncontrollably in the bone marrow and blood, and the cancer has returned after a period of remission.
Coding Tips
- •Confirm prior remission was documented before coding relapse status
- •Relapse indicates disease recurrence after a disease-free interval
Clinical Significance
Mast cell leukemia in relapse indicates recurrence after the rare achievement of remission in this extremely aggressive mast cell neoplasm. Relapsed mast cell leukemia carries a dismal prognosis, with very limited effective salvage options and consideration for clinical trial enrollment or experimental therapies.
Documentation Requirements
- ✓Documentation must confirm prior remission with subsequent return of disease markers including rising serum tryptase, reappearance of bone marrow mast cell infiltration, circulating mast cells, or recurrent organ damage.
- ✓The prior remission history and current salvage therapy plan should be detailed.
Commonly Confused Codes
Code Hierarchy
└C94Other leukemias of specified cell type└C94.3Mast cell leukemia└C94.32Mast cell leukemia, in relapse
└C94.32Mast cell leukemia, in relapse