C92.A0

HCC Category Mapping

What This Code Means

A type of acute myeloid leukemia where multiple cell lines show abnormal development and the cancer has not responded adequately to initial treatment.

Coding Tips

• •Multilineage dysplasia is a morphologic finding that should be documented in the pathology report
• •Confirm this is not a myelodysplastic syndrome but rather acute myeloid leukemia with dysplastic features

Clinical Significance

Acute myeloid leukemia with multilineage dysplasia (AML-MLD) is an AML subtype characterized by dysplastic changes in two or more myeloid cell lines (erythroid, granulocytic, megakaryocytic), often arising from prior myelodysplastic syndrome (MDS). AML-MLD typically occurs in older adults and carries an adverse prognosis compared to de novo AML without dysplasia. The 'not in remission' status indicates active disease requiring treatment.

Documentation Requirements

• ✓Documentation must confirm the presence of multilineage dysplasia (dysplasia in 50% or more of cells in at least two myeloid lineages) on bone marrow examination.
• ✓Prior history of MDS should be documented if present, as this supports the diagnosis.
• ✓Cytogenetic and molecular testing results, blast percentage, and MDS-related changes should be recorded.
• ✓Treatment response and current disease status must be explicitly stated.

Commonly Confused Codes