C92.52

HCC Category Mapping

What This Code Means

A type of blood cancer (acute myelomonocytic leukemia) where the cancer has returned after a period of remission.

Coding Tips

• •Relapse indicates the cancer has recurred after achieving remission; this is distinct from initial presentation
• •Document the timeline of remission and relapse when available for clinical context

Clinical Significance

Acute myelomonocytic leukemia in relapse indicates recurrence of the dual myeloid/monocytic leukemia after achieving prior remission. Relapsed AMML requires salvage chemotherapy and often allogeneic stem cell transplantation. The prognosis at relapse depends on duration of first remission, cytogenetic features, and transplant candidacy. Extramedullary relapse (skin, CNS) may occur and should be specifically evaluated.

Documentation Requirements

• ✓Documentation must confirm prior remission and current evidence of relapse including rising blasts with myeloid and monocytic differentiation, recurrent extramedullary involvement, or abnormal cytogenetics.
• ✓Duration of first remission, prior treatment regimens, and updated molecular/cytogenetic testing at relapse must be recorded.
• ✓Salvage treatment plan and transplant candidacy assessment should be documented.

Commonly Confused Codes