C92.21

HCC Category Mapping

What This Code Means

A rare type of myeloid leukemia without the typical genetic mutation, where the patient's cancer is in remission.

Coding Tips

• •Verify remission status is explicitly documented by the physician
• •Ensure BCR/ABL-negative status is confirmed in diagnostic testing

Clinical Significance

Atypical chronic myeloid leukemia, BCR/ABL-negative, in remission indicates that this rare myelodysplastic/myeloproliferative neoplasm has responded to treatment. Remission in aCML is uncommon given the limited treatment options and aggressive disease biology. Allogeneic stem cell transplantation is the only potentially curative approach, and remission may be achieved through transplant or hypomethylating agent therapy.

Documentation Requirements

• ✓Documentation must confirm BCR/ABL-negative status and explicitly state remission status with supporting evidence including normalized blood counts and bone marrow findings.
• ✓The treatment that achieved remission (transplant, hypomethylating agents, or other therapy) and date of remission should be recorded.
• ✓Ongoing surveillance plan and GVHD management (if post-transplant) must be documented.

Commonly Confused Codes