C92.00

HCC Category Mapping

What This Code Means

An acute blood cancer of myeloid cells that has not responded to treatment or is actively progressing.

Coding Tips

• •This code specifically indicates acute myeloblastic leukemia without remission achievement
• •Verify documentation confirms 'acute' type and 'not in remission' status

Clinical Significance

Acute myeloblastic leukemia (AML) not in remission is a rapidly progressive hematologic malignancy characterized by clonal proliferation of immature myeloid cells (blasts) in the bone marrow, with blast count of 20% or more. AML is a medical emergency requiring immediate induction chemotherapy, and it carries a high risk of life-threatening complications including neutropenic infections, bleeding, and disseminated intravascular coagulation. The 'not in remission' status indicates active, uncontrolled disease.

Documentation Requirements

• ✓Documentation must confirm the acute nature of the leukemia with blast percentage, morphologic classification (FAB or WHO 2022), cytogenetic findings, and molecular mutations (FLT3, NPM1, CEBPA, IDH1/2, TP53).
• ✓Active disease status must be explicitly stated.
• ✓Treatment history, response assessment, and current supportive care needs (transfusions, growth factors, antimicrobials) should be documented.

Commonly Confused Codes