C90.22
BillableExtramedullary plasmacytoma in relapse
HCC Category Mapping
V28HCC 19 — Lymphoma and Other Cancers
0.105V24HCC 9 — Lung and Other Severe Cancers
0.973ESRDHCC 9 — Lung and Other Severe Cancers
0.000RxHCCHCC 16 — Multiple Myeloma and Plasma Cell Neoplasms
0.000What This Code Means
A rare cancer of plasma cells located outside the bone marrow that has returned after a period of remission.
Coding Tips
- •Relapse indicates the cancer has recurred after previous remission; ensure documentation clearly states relapse or recurrence
- •Do not confuse relapse with initial diagnosis or progression during active treatment
Clinical Significance
Extramedullary plasmacytoma in relapse indicates recurrence of the plasma cell tumor after achieving remission. Relapse may occur at the original site or at new extramedullary locations. Recurrence also raises concern for progression to systemic multiple myeloma, which requires comprehensive restaging workup. Treatment of relapsed disease may require different modalities than the initial approach.
Documentation Requirements
- ✓Documentation must demonstrate recurrence of the plasmacytoma after a documented period of remission, confirmed by imaging and biopsy.
- ✓Restaging workup including bone marrow biopsy and protein studies to exclude myeloma transformation, relapse location, new treatment plan, and disease extent must be recorded.
Commonly Confused Codes
Code Hierarchy
└C90Multiple myeloma and malignant plasma cell neoplasms└C90.2Extramedullary plasmacytoma└C90.22Extramedullary plasmacytoma in relapse
└C90.22Extramedullary plasmacytoma in relapse