C88.00
BillableWaldenström macroglobulinemia not having achieved remission
HCC Category Mapping
V28HCC 21 — Breast, Prostate, Colorectal and Other Cancers and Tumors
0.545V24HCC 23 — Other Significant Endocrine and Metabolic Disorders
0.230ESRDHCC 23 — Other Significant Endocrine and Metabolic Disorders
0.000RxHCCHCC 19 — Lymphoma and Other Cancers
0.000What This Code Means
A rare blood cancer where abnormal plasma cells produce excessive immunoglobulin M protein, and the disease has not responded adequately to treatment.
Coding Tips
- •Distinguish between remission (C88.01) and non-remission status based on clinical response to therapy
- •Document laboratory findings including serum protein levels and immunoglobulin M quantification
Clinical Significance
Waldenstrom macroglobulinemia (lymphoplasmacytic lymphoma) is an indolent B-cell neoplasm characterized by bone marrow infiltration by lymphoplasmacytic cells producing monoclonal immunoglobulin M. The elevated immunoglobulin M can cause hyperviscosity syndrome with neurologic symptoms, bleeding, and visual disturbances. Non-remission status indicates ongoing disease requiring active management of both the neoplasm and its immunoglobulin M-related complications.
Documentation Requirements
- ✓Documentation must include confirmation through bone marrow biopsy showing lymphoplasmacytic infiltrate and serum protein electrophoresis demonstrating the immunoglobulin M monoclonal spike.
- ✓Immunoglobulin M quantification, viscosity levels if symptomatic, hemoglobin, treatment regimen, and non-remission status must be documented.
Commonly Confused Codes
Code Hierarchy
└C88Malignant immunoproliferative diseases and certain other B-cell lymphomas└C88.0Waldenström macroglobulinemia└C88.00Waldenström macroglobulinemia not having achieved remission
└C88.00Waldenström macroglobulinemia not having achieved remission