C85.99

HCC Category Mapping

What This Code Means

Non-Hodgkin lymphoma of unspecified type affecting organs or tissues outside the lymph node system.

Coding Tips

• •Extranodal sites include organs like liver, bone, GI tract, CNS, and other solid organs
• •Specify which organ(s) are involved in documentation for optimal coding accuracy

Clinical Significance

Non-Hodgkin lymphoma of unspecified type affecting extranodal and solid organ sites represents lymphoma arising in or primarily involving organs outside the lymph node system, such as the gastrointestinal tract, central nervous system, liver, bone, or skin. Extranodal NHL accounts for approximately one-third of all NHL cases and may present with organ-specific symptoms that mimic non-malignant conditions. Prognosis and treatment vary significantly depending on the organ involved.

Documentation Requirements

• ✓Provider must specify which extranodal organ or solid organ site is involved.
• ✓Pathology confirming NHL with immunohistochemistry results should be documented.
• ✓Disease stage, treatment approach (which may differ based on organ site), and response to therapy must be clearly recorded.

Commonly Confused Codes