C85.97
BillableNon-Hodgkin lymphoma, unspecified, spleen
HCC Category Mapping
V28HCC 21 — Breast, Prostate, Colorectal and Other Cancers and Tumors
0.545V24HCC 10 — Lymphoma and Other Cancers
0.675ESRDHCC 10 — Lymphoma and Other Cancers
0.000RxHCCHCC 21 — Hodgkin Lymphoma and Other Cancers
0.000What This Code Means
Non-Hodgkin lymphoma of unspecified type affecting the spleen.
Coding Tips
- •The spleen is an extranodal site; confirm splenic involvement is documented
- •Splenic involvement may occur with or without lymph node involvement
Clinical Significance
Non-Hodgkin lymphoma of unspecified type involving the spleen represents an extranodal presentation with significant implications for immune function and disease staging. Splenic involvement often manifests as splenomegaly detectable on physical examination or imaging, and may cause cytopenias through hypersplenism. Splenic lymphoma can be the predominant site of disease or part of a more disseminated process.
Documentation Requirements
- ✓Provider must document splenic involvement through imaging (CT, PET-CT, or ultrasound showing splenomegaly or focal lesions) or pathology from splenectomy specimens.
- ✓The specific NHL subtype should be sought through tissue analysis.
- ✓Disease stage, treatment plan, spleen size measurements, and associated cytopenias should be recorded.
Commonly Confused Codes
C85.98 (lymph nodes of multiple sites) should be used when multiple nodal regions are involved alongside splenic disease.D73.89 (other diseases of spleen) is for non-neoplastic splenic conditions.C85.99 (extranodal and solid organ sites) covers other organ involvement but the spleen has its own specific code.
Code Hierarchy
└C85Other specified and unspecified types of non-Hodgkin lymphoma└C85.9Non-Hodgkin lymphoma, unspecified└C85.97Non-Hodgkin lymphoma, unspecified, spleen
└C85.97Non-Hodgkin lymphoma, unspecified, spleen