What is ICD-10 code C85.88?

C85.88 is the ICD-10-CM diagnosis code for Other specified types of non-Hodgkin lymphoma, lymph nodes of multiple sites. A rare or unusual type of non-Hodgkin lymphoma affecting lymph nodes in multiple locations throughout the body. It belongs to the ICD-10-CM chapter for neoplasms (c00-d49). C85.88 is a billable code, meaning it can be reported on a claim as a primary or secondary diagnosis when supported by documentation. C85.88 is part of the FY2026 ICD-10-CM code set published by the CMS National Center for Health Statistics and used on Medicare, Medicaid, and commercial claims in the United States.

Yes. C85.88 is a billable ICD-10-CM code that can be reported on professional and institutional claims as a primary or secondary diagnosis when the provider documentation supports the specific condition described. Billable codes in ICD-10-CM are coded to the highest level of specificity available for the documented diagnosis. C85.88 is current for fiscal year 2026 and remains in the active CMS ICD-10-CM code set published by the National Center for Health Statistics.

What is the V28 vs V24 difference for C85.88?

CMS phased in the V28 risk adjustment model over payment years 2024 (33%), 2025 (67%), and 2026 (100%), replacing V24. V28 consolidates HCC categories, removes some lower-acuity conditions, and recalibrates RAF weights across the entire model. For C85.88, V28 maps to Lymphoma and Other Cancers at RAF 0.671 while V24 mapped to Lymphoma and Other Cancers at RAF 0.675. Both models can still appear in legacy data and in payer-specific lookback periods.

What should coders know when reporting C85.88?

Use this code when the specified lymphoma type involves lymph nodes at two or more distant sites Document all involved sites in the medical record for treatment planning purposes Because C85.88 maps to a payment HCC, the documentation must also satisfy MEAT criteria (Monitor, Evaluate, Assess, or Treat) for the encounter to count toward the patient's risk adjustment score.

2026 ICD-10-CM C85.88: Other specified types

ICD-10-CM Code View

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Code lookupC85.88Effective periodFY2026 Apr Update (Apr 1-Sep 30)

FY 2026 Apr update / Neoplasms (C00-D49) / Malignant neoplasms of lymphoid, hematopoietic and related tissue (C81-C96)

C85.88

Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidance

Other specified types of non-Hodgkin lymphoma, lymph nodes of multiple sites

A rare or unusual type of non-Hodgkin lymphoma affecting lymph nodes in multiple locations throughout the body.

Buddy Insight

Other specified non-Hodgkin lymphoma involving lymph nodes of multiple sites captures rare, named NHL subtypes at a defined anatomical location.

CMS-HCC V28

Mapped

HCC 21

Lymphoma and Other Cancers

RAF 0.671

CMS-HCC V24

Mapped

HCC 10

Lymphoma and Other Cancers

RAF 0.675

ACA/HHS

Mapped

HCC 10

HHS-HCC 10

Varies by metal level

ESRD/PACE

Mapped

HCC 10

Lymphoma and Other Cancers

RAF 0.111

RXHCC

Mapped

HCC 21

Hodgkin Lymphoma and Other Ca...

RAF 0.410

Code Book Path

Official

C85Other specified and unspecified types of non-Hodgkin lymphoma

C85.8Other specified types of non-Hodgkin lymphoma

C85.88Other specified types of non-Hodgkin lymphoma, lymph nodes of multiple sites

Inclusion Terms

Official

ICD-10-CM does not list inclusion terms for C85.88 in this effective period.

Excludes 2

Official

ICD-10-CM does not list Excludes 2 notes for C85.88 in this effective period.

Related Child Codes

Official

C85.80Other specified types of non-Hodgkin lymphoma, unspecified site

C85.81Other specified types of non-Hodgkin lymphoma, lymph nodes of head, face, and neck

C85.82Other specified types of non-Hodgkin lymphoma, intrathoracic lymph nodes

C85.83Other specified types of non-Hodgkin lymphoma, intra-abdominal lymph nodes

C85.84Other specified types of non-Hodgkin lymphoma, lymph nodes of axilla and upper limb

Includes

Official

ICD-10-CM does not list Includes notes for C85.88 in this effective period.

Excludes 1

Official

ICD-10-CM does not list Excludes 1 notes for C85.88 in this effective period.

Code First

Official

ICD-10-CM does not list Code First sequencing instructions for C85.88 in this effective period.

Use Additional

Official

ICD-10-CM does not list Use Additional Code instructions for C85.88 in this effective period.

Code Also

Official

ICD-10-CM does not list Code Also instructions for C85.88 in this effective period.

Buddy Documentation Tip

HCC Buddy guidance

Pathology confirming the specific NHL subtype by WHO classification (with immunophenotyping and molecular studies)

Imaging or clinical documentation confirming involvement of lymph nodes of multiple sites

Verification that no more specific ICD-10 code exists for this NHL subtype

Staging information and treatment plan

MEAT Support

HCC Buddy guidance

Pathology confirming the specific NHL subtype by WHO classification (with immunophenotyping and molecular studies)

Imaging or clinical documentation confirming involvement of lymph nodes of multiple sites

Verification that no more specific ICD-10 code exists for this NHL subtype

Staging information and treatment plan

Audit Caution

HCC Buddy guidance

Selecting C85.8x when a more specific lymphoma code exists in C82 (follicular), C83 (DLBCL, mantle cell, Burkitt), or C86 categories

Using unspecified site when documentation clearly identifies lymph nodes of multiple sites

Not querying for the specific NHL subtype name to verify correct category assignment

Miscoding site-specific 5th character — verify the correct anatomical designation

Common Mistakes

HCC Buddy guidance

C85.80 (Other specified NHL, unspecified site) — Use the site-specific code when lymph nodes of multiple sites is documented

C83.x or C82.x (specific NHL subtypes at same site) — Verify the subtype does not have its own code in C82-C84 or C86

C85.88 (Other specified NHL, lymph nodes of multiple sites) — Use site-specific code for single-site involvement; use C85.88 for multiple regions

Current with CMS: FY2026 ICD-10-CM Apr 1 update (effective Apr 1 – Sep 30, 2026) · CMS-HCC V28, 100% phased in for payment year 2026. FY2027 code set already staged for October 1, 2026. How HCC Buddy stays current →

Is C85.88 an HCC code?

Yes. C85.88 (Other specified types of non-Hodgkin lymphoma, lymph nodes of multiple sites) maps to Lymphoma and Other Cancers under the CMS-HCC V28 risk adjustment model (and Lymphoma and Other Cancers under V24), with a community non-dual aged RAF of 0.671. It is billable for payment year 2026.

Coder answer: C85.88 is billable and maps to V28 HCC 21, Lymphoma and Other Cancers. Open it in the Code Book for the tabular path, RAF, and MEAT checklist.

Code: C85.88
Description: Other specified types of non-Hodgkin lymphoma, lymph nodes of multiple sites
HCC (V28): HCC 21 — Lymphoma and Other Cancers
RAF: 0.671
Billable: Yes
Payment year: 2026

HCC Category Mapping

V28HCC 21, Lymphoma and Other Cancers

0.671

V24HCC 10, Lymphoma and Other Cancers

0.675

ESRDHCC 10, Lymphoma and Other Cancers

0.111

RxHCCHCC 21, Hodgkin Lymphoma and Other Cancers

0.410

Each model's RAF is its CMS base weight for that model's standard population, so weights are not directly comparable across models: CMS-HCC V28 and V24 use Community, Non-Dual, Aged; ESRD uses the dialysis continuing-enrollee model; RxHCC is the Part D continuing-enrollee, non-low-income, aged weight (a larger scale than CMS-HCC). ACA/HHS has no single weight — it varies by metal level. Actual per-patient RAF contribution depends on member segment, interactions, and the model year used by the payer. V28 is the CMS-HCC model phased in over payment years 2024–2026; V24 remains in use during the transition and for historical data.

Work C85.88 in the Code Book — tabular path, V28 RAF, and MEAT checklist →

MEAT Criteria for C85.88

For C85.88 to count as a valid HCC diagnosis in a given encounter, the provider's documentation must show MEAT: Monitor, Evaluate, Assess, or Treat. A diagnosis from a prior year does not carry forward automatically, it has to be re-documented and supported each calendar year.

MMonitor: signs, symptoms, disease progression, or lab trending documented in the note
EEvaluate: test results, medication response, or physical findings reviewed by the provider
AAssess: explicit mention in the assessment or plan with acknowledgment of status
TTreat: medication, referral, procedure, therapy, or counseling tied to the diagnosis

Only one of M/E/A/T is required to support the code, but the documentation must be specific enough to show that the provider actually addressed C85.88 during that encounter, not just copy-forwarded from a problem list.

Coder workflow notes

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What This Code Means

C85.88 is the ICD-10-CM diagnosis code for other specified types of non-hodgkin lymphoma, lymph nodes of multiple sites. A rare or unusual type of non-Hodgkin lymphoma affecting lymph nodes in multiple locations throughout the body. C85.88 sits in the ICD-10-CM chapter for neoplasms (c00-d49), within the section covering malignant neoplasms of lymphoid, hematopoietic and related tissue (c81-c96).

Under the CMS-HCC V28 risk adjustment model, C85.88 maps to Lymphoma and Other Cancers (HCC 21) with a community, non-dual, aged base RAF weight of 0.671. Under the older V24 model, C85.88 mapped to the same category but with a base RAF weight of 0.675, V28 recalibrated weights across the entire model. V28 is the CMS-HCC risk adjustment model that reached 100% phase-in for payment year 2026, replacing V24 which was used during the PY2024–PY2025 transition.

Use this code when the specified lymphoma type involves lymph nodes at two or more distant sites. Because C85.88 maps to a payment HCC, the provider's documentation must satisfy MEAT criteria (Monitor, Evaluate, Assess, or Treat) for the encounter to count toward the patient's Medicare Advantage risk adjustment score. When documentation is ambiguous, coders should issue a provider query rather than assume the highest-specificity variant.

HCC Buddy maintains structured V28 and V24 mapping, RAF weights, and MEAT documentation criteria for C85.88 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.

Coding Tips

•Use this code when the specified lymphoma type involves lymph nodes at two or more distant sites
•Document all involved sites in the medical record for treatment planning purposes

Clinical Significance

Other specified non-Hodgkin lymphoma involving lymph nodes of multiple sites captures rare, named NHL subtypes at a defined anatomical location. Accurate site-specific coding supports treatment planning, radiation field design, and outcomes tracking. These lymphoma subtypes often have distinct clinical behaviors and treatment requirements compared to common NHL types.

Documentation Requirements

✓Pathology confirming the specific NHL subtype by WHO classification (with immunophenotyping and molecular studies)
✓Imaging or clinical documentation confirming involvement of lymph nodes of multiple sites
✓Verification that no more specific ICD-10 code exists for this NHL subtype
✓Staging information and treatment plan

Commonly Confused Codes

•C85.80 (Other specified NHL, unspecified site): Use the site-specific code when lymph nodes of multiple sites is documented
•C83.x or C82.x (specific NHL subtypes at same site): Verify the subtype does not have its own code in C82-C84 or C86
•C85.88 (Other specified NHL, lymph nodes of multiple sites): Use site-specific code for single-site involvement; use C85.88 for multiple regions