C84.72
BillableAnaplastic large cell lymphoma, ALK-negative, intrathoracic lymph nodes
HCC Category Mapping
V28HCC 19 — Lymphoma and Other Cancers
0.105V24HCC 10 — Lymphoma and Other Cancers
0.675ESRDHCC 10 — Lymphoma and Other Cancers
0.000RxHCCHCC 21 — Hodgkin Lymphoma and Other Cancers
0.000What This Code Means
A type of aggressive lymphoma (cancer of immune cells) without a specific genetic marker (ALK-negative) that is located in the lymph nodes within the chest cavity.
Coding Tips
- •Confirm involvement of mediastinal, hilar, or other intrathoracic lymph nodes through imaging reports (CT or PET scans)
- •Document whether involvement is unilateral or bilateral if specified in the clinical documentation
Clinical Significance
Anaplastic large cell lymphoma, ALK-negative, involving intrathoracic lymph nodes represents mediastinal or hilar nodal disease from an aggressive T-cell lymphoma without the favorable ALK marker. Intrathoracic involvement can cause respiratory symptoms, superior vena cava syndrome, or pleural effusions. The ALK-negative status requires more intensive treatment strategies.
Documentation Requirements
- ✓Pathology confirming ALCL ALK-negative with CD30 positivity
- ✓Chest CT or PET/CT documenting intrathoracic lymph node involvement
- ✓T-cell immunophenotype on immunohistochemistry
- ✓Clinical staging with notation of bulky disease
- ✓ALK-negative status confirmed by testing
Commonly Confused Codes
C84.62 — ALCL ALK-positive, intrathoracic: Different ALK status with better prognosisC84.42 — PTCL-NOS, intrathoracic: Different subtype without ALCL morphologic featuresC85.22 — Mediastinal large B-cell lymphoma: B-cell origin; can mimic ALCL in mediastinumC84.92 — Mature T/NK-cell lymphoma, unspecified, intrathoracic: Less specific; ALCL should be coded when confirmed
Code Hierarchy
└C84Mature T/NK-cell lymphomas└C84.7Anaplastic large cell lymphoma, ALK-negative└C84.72Anaplastic large cell lymphoma, ALK-negative, intrathoracic lymph nodes
└C84.72Anaplastic large cell lymphoma, ALK-negative, intrathoracic lymph nodes