C84.48
BillablePeripheral T-cell lymphoma, not elsewhere classified, lymph nodes of multiple sites
HCC Category Mapping
V28HCC 19 — Lymphoma and Other Cancers
0.105V24HCC 10 — Lymphoma and Other Cancers
0.675ESRDHCC 10 — Lymphoma and Other Cancers
0.000RxHCCHCC 21 — Hodgkin Lymphoma and Other Cancers
0.000What This Code Means
A type of cancer affecting T-cells that is not classified elsewhere, involving lymph nodes in multiple locations throughout the body.
Coding Tips
- •Document that multiple lymph node sites are involved, not just a single region
- •Ensure this is not a more specific lymphoma subtype with better classification
Clinical Significance
Peripheral T-cell lymphoma not elsewhere classified involving lymph nodes of multiple sites indicates advanced-stage disease with widespread nodal involvement across two or more anatomical regions. This typically corresponds to Ann Arbor stage III or IV disease and carries a worse prognosis than single-site involvement. Accurate coding of multi-site disease reflects the true disease burden.
Documentation Requirements
- ✓Pathology confirming PTCL-NOS diagnosis with immunophenotyping
- ✓Imaging (PET/CT preferred) documenting involvement in at least two distinct lymph node regions
- ✓Specific identification of all involved lymph node regions in clinical documentation
- ✓Ann Arbor staging (expected stage III or IV)
- ✓Active disease status confirmed
Commonly Confused Codes
C84.41 through C84.47 — Site-specific PTCL-NOS codes: Use these when only one anatomical region is involved; C84.48 is for documented involvement of two or more regionsC84.40 — PTCL-NOS, unspecified site: Use C84.40 only when the location is truly unknown; if multiple sites are documented, C84.48 is correctC84.49 — PTCL-NOS, extranodal/solid organ: C84.48 is for lymph node involvement at multiple sites; C84.49 is for disease outside of lymph nodes entirely
Code Hierarchy
└C84Mature T/NK-cell lymphomas└C84.4Peripheral T-cell lymphoma, not elsewhere classified└C84.48Peripheral T-cell lymphoma, not elsewhere classified, lymph nodes of multiple sites
└C84.48Peripheral T-cell lymphoma, not elsewhere classified, lymph nodes of multiple sites