C82.59

HCC Category Mapping

What This Code Means

This is a type of cancer that starts in the lymph system (specifically in follicle center cells) and has spread to organs outside the lymph nodes, such as the liver, lungs, or other solid organs. It is a slow-growing form of lymphoma that affects areas beyond the typical lymph node locations.

Coding Tips

• •Verify documentation specifies both the diffuse follicle center lymphoma type AND the extranodal/solid organ site involvement before assigning this code
• •Ensure the site of involvement is clearly documented (e.g., liver, lung, GI tract) as this specificity is required for accurate coding of extranodal disease

Clinical Significance

Diffuse follicle center lymphoma at extranodal and solid organ sites represents stage IV disease with involvement beyond the lymphatic system. Common extranodal sites include bone marrow, gastrointestinal tract, liver, lungs, and skin. Extranodal spread indicates more aggressive disease behavior and typically requires combination chemoimmunotherapy. The specific organs involved can significantly impact treatment approach, prognosis, and potential complications.

Documentation Requirements

• ✓Pathology confirming diffuse follicle center lymphoma at the extranodal site
• ✓Specific identification of which extranodal organs are involved
• ✓Biopsy confirmation of extranodal involvement (not just imaging)
• ✓Staging documentation with stage IV designation
• ✓Assessment of organ function impacted by the lymphoma (liver function, renal function, etc.)
• ✓Documentation of any complications from extranodal disease

Commonly Confused Codes