C82.58

Billable

Diffuse follicle center lymphoma, lymph nodes of multiple sites

HCC Category Mapping

V28HCC 21 — Breast, Prostate, Colorectal and Other Cancers and Tumors

0.545

V24HCC 10 — Lymphoma and Other Cancers

0.675

ESRDHCC 10 — Lymphoma and Other Cancers

0.000

RxHCCHCC 21 — Hodgkin Lymphoma and Other Cancers

0.000

What This Code Means

A type of non-Hodgkin lymphoma affecting follicle center cells that involves lymph nodes in multiple different body locations.

Coding Tips

•Document which specific sites are involved to support medical necessity
•Ensure this code is used only when lymph nodes in 2 or more distinct regions are affected

Clinical Significance

Diffuse follicle center lymphoma involving lymph nodes at multiple sites represents disseminated nodal disease that is typically stage III or IV. Multi-site involvement implies systemic disease requiring systemic therapy rather than localized approaches. The diffuse growth pattern combined with widespread distribution suggests this is a more aggressive presentation than typical indolent follicular lymphoma, warranting closer monitoring and potentially earlier treatment initiation.

Documentation Requirements

✓Pathology confirming diffuse follicle center lymphoma histology
✓Imaging documenting lymph node involvement in at least two distinct anatomic regions
✓Specification of all involved nodal regions in the medical record
✓Staging documentation reflecting multi-site involvement
✓Treatment plan addressing systemic disease
✓Response assessment criteria (Lugano or equivalent)

Commonly Confused Codes

C82.59 — Diffuse follicle center lymphoma, extranodal and solid organ sites: Use C82.58 for multi-site nodal disease; use C82.59 when non-lymph node organs are involved C82.88 — Other types of follicular lymphoma, lymph nodes of multiple sites: Use C82.58 when pathology specifically identifies diffuse follicle center type C82.50 — Diffuse follicle center lymphoma, unspecified site: Use C82.58 when multiple sites are documented, not the unspecified code

Code Hierarchy

└C82Follicular lymphoma └C82.5Diffuse follicle center lymphoma └C82.58Diffuse follicle center lymphoma, lymph nodes of multiple sites

└C82.58Diffuse follicle center lymphoma, lymph nodes of multiple sites