C82.58 ICD-10-CM Code: Diffuse follicle center lymphoma, lymph nodes of multiple sites
C82.58 maps to CMS-HCC V28 21. A source-labeled RAF reference is available. Confirm the documented diagnosis and applicable coding requirements. MEAT criteria · RAF Calculator · HCC coding software
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FY 2026 Apr update / Neoplasms (C00-D49) / Malignant neoplasms of lymphoid, hematopoietic and related tissue (C81-C96)
C82.58
Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidanceDiffuse follicle center lymphoma, lymph nodes of multiple sites
A type of non-Hodgkin lymphoma affecting follicle center cells that involves lymph nodes in multiple different body locations.
Buddy Insight
Diffuse follicle center lymphoma involving lymph nodes at multiple sites represents disseminated nodal disease that is typically stage III or IV.
CMS-HCC V28
MappedHCC 21
Code-level coefficient reference
CMS-HCC V24
HistoricalHistorical
Not used for CY2026 payment
ACA/HHS
MappedHCC 010
Code-level coefficient reference
ESRD/PACE
MappedHCC 10
Code-level coefficient reference
RXHCC
MappedHCC 21
Code-level coefficient reference
Code Book Path
Inclusion Terms
OfficialNo inclusion terms are included in this display for C82.58. Check the code and parent instructions in the Code Book.
Excludes 2
Official- Kaposi's sarcoma of lymph nodes (C46.3)Inherited from C81-C96
- secondary and unspecified neoplasm of lymph nodes (C77.-)Inherited from C81-C96
- secondary neoplasm of bone marrow (C79.52)Inherited from C81-C96
- secondary neoplasm of spleen (C78.89)Inherited from C81-C96
Related Codes
Includes
Official- follicular lymphoma with or without diffuse areasInherited from C82
Excludes 1
Official- mature T/NK-cell lymphomas (C84.-)Inherited from C82
- personal history of non-Hodgkin lymphoma (Z85.72)Inherited from C82
Code First
OfficialNo Code First sequencing instructions are included in this display for C82.58. Check the code and parent instructions in the Code Book.
Use Additional
OfficialNo Use Additional Code instructions are included in this display for C82.58. Check the code and parent instructions in the Code Book.
Code Also
OfficialNo Code Also instructions are included in this display for C82.58. Check the code and parent instructions in the Code Book.
Buddy Documentation Tip
MEAT Support
Audit Caution
Common Mistakes
Current with CMS: FY2026 ICD-10-CM Apr 1 update (effective Apr 1 – Sep 30, 2026) · CMS-HCC V28, 100% phased in for payment year 2026. FY2027 code set already staged for October 1, 2026. How HCC Buddy stays current →
Is C82.58 an HCC code?
Yes. C82.58 (Diffuse follicle center lymphoma, lymph nodes of multiple sites) maps to HCC 21, Lymphoma and Other Cancers under the CMS-HCC V28 risk adjustment model, with a source-labeled community non-dual aged reference coefficient of 0.671. Source-labeled code-level coefficients are references, not member totals. Actual contribution depends on complete member context, hierarchy and cleanup rules, interactions, and model year. HCC Buddy's RAF Calculator supports CMS-HCC V28 PY2026 and shows no score unless every required source and calculation check passes. It is billable for payment year 2026.
Coder answer: C82.58 is billable and maps to V28 HCC 21, Lymphoma and Other Cancers. Open it in the Code Book for the tabular path, RAF, and MEAT checklist.
- Code
- C82.58
- Description
- Diffuse follicle center lymphoma, lymph nodes of multiple sites
- HCC (V28)
- HCC 21 — Lymphoma and Other Cancers
- RAF reference coefficient
- 0.671
- Billable
- Yes
- Payment year
- 2026
HCC Category Mapping
These are source-labeled model coefficients, not member totals. A category may still be removed by hierarchy or model cleanup rules. Weights are not directly comparable across models: CMS-HCC V28 and V24 use Community, Non-Dual, Aged; ESRD uses the dialysis continuing-enrollee model; RxHCC is the Part D continuing-enrollee, non-low-income, aged weight (a larger scale than CMS-HCC). ACA/HHS has no single weight — it varies by metal level. Actual per-patient RAF contribution depends on member context, hierarchy and cleanup rules, interactions, and the model year used by the payer. V28 is the CMS-HCC model phased in over payment years 2024–2026; V24 remains available for historical review.
Work C82.58 in the Code Book — tabular path, V28 RAF reference, and MEAT checklist →
MEAT review for C82.58
For C82.58, confirm that the documentation supports the diagnosis and meets the applicable coding, encounter, program and payer requirements. MEAT (Monitor, Evaluate, Assess, or Treat) is a review mnemonic, not a universal CMS coding rule.
- MMonitor: signs, symptoms, disease progression, or lab trending documented in the note
- EEvaluate: test results, medication response, or physical findings reviewed by the provider
- AAssess: explicit mention in the assessment or plan with acknowledgment of status
- TTreat: medication, referral, procedure, therapy, or counseling tied to the diagnosis
Coder workflow notes
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What This Code Means
C82.58 is the ICD-10-CM diagnosis code for diffuse follicle center lymphoma, lymph nodes of multiple sites. A type of non-Hodgkin lymphoma affecting follicle center cells that involves lymph nodes in multiple different body locations. C82.58 sits in the ICD-10-CM chapter for neoplasms (c00-d49), within the section covering malignant neoplasms of lymphoid, hematopoietic and related tissue (c81-c96).
Under the CMS-HCC V28 risk adjustment model, C82.58 maps to Lymphoma and Other Cancers (HCC 21) with a source-labeled community, non-dual, aged reference coefficient of 0.671. No V24 mapping is shown for C82.58; use the applicable model and payment year when reviewing the V28 mapping. For CY2026 non-PACE Medicare Advantage, CMS uses 100% of the 2024 CMS-HCC model (V28). PACE uses a separate model blend. Source-labeled code-level coefficients are references, not member totals. Actual contribution depends on complete member context, hierarchy and cleanup rules, interactions, and model year. HCC Buddy's RAF Calculator supports CMS-HCC V28 PY2026 and shows no score unless every required source and calculation check passes.
Document which specific sites are involved to support medical necessity. For C82.58, confirm that the documentation supports the diagnosis and meets the applicable coding, encounter, program and payer requirements. MEAT (Monitor, Evaluate, Assess, or Treat) is a review mnemonic, not a universal CMS coding rule. When documentation is ambiguous, coders should issue a provider query rather than assume the highest-specificity variant.
HCC Buddy maintains structured V28 and V24 mapping, source-labeled coefficient references, and MEAT documentation criteria for C82.58 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.
Coding Tips
- •Document which specific sites are involved to support medical necessity
- •Ensure this code is used only when lymph nodes in 2 or more distinct regions are affected
Clinical Significance
Diffuse follicle center lymphoma involving lymph nodes at multiple sites represents disseminated nodal disease that is typically stage III or IV. Multi-site involvement implies systemic disease requiring systemic therapy rather than localized approaches. The diffuse growth pattern combined with widespread distribution suggests this is a more aggressive presentation than typical indolent follicular lymphoma, warranting closer monitoring and potentially earlier treatment initiation.
Documentation Requirements
- ✓Pathology confirming diffuse follicle center lymphoma histology
- ✓Imaging documenting lymph node involvement in at least two distinct anatomic regions
- ✓Specification of all involved nodal regions in the medical record
- ✓Staging documentation reflecting multi-site involvement
- ✓Treatment plan addressing systemic disease
- ✓Response assessment criteria (Lugano or equivalent)
Commonly Confused Codes
- •C82.59: Diffuse follicle center lymphoma, extranodal and solid organ sites: Use C82.58 for multi-site nodal disease; use C82.59 when non-lymph node organs are involved
- •C82.88: Other types of follicular lymphoma, lymph nodes of multiple sites: Use C82.58 when pathology specifically identifies diffuse follicle center type
- •C82.50: Diffuse follicle center lymphoma, unspecified site: Use C82.58 when multiple sites are documented, not the unspecified code