What is ICD-10 code C82.58?

C82.58 is the ICD-10-CM diagnosis code for Diffuse follicle center lymphoma, lymph nodes of multiple sites. A type of non-Hodgkin lymphoma affecting follicle center cells that involves lymph nodes in multiple different body locations. It belongs to the ICD-10-CM chapter for neoplasms (c00-d49). C82.58 is a billable code, meaning it can be reported on a claim as a primary or secondary diagnosis when supported by documentation. C82.58 is part of the FY2026 ICD-10-CM code set published by the CMS National Center for Health Statistics and used on Medicare, Medicaid, and commercial claims in the United States.

Yes. C82.58 is a billable ICD-10-CM code that can be reported on professional and institutional claims as a primary or secondary diagnosis when the provider documentation supports the specific condition described. Billable codes in ICD-10-CM are coded to the highest level of specificity available for the documented diagnosis. C82.58 is current for fiscal year 2026 and remains in the active CMS ICD-10-CM code set published by the National Center for Health Statistics.

What is the V28 vs V24 difference for C82.58?

CMS phased in the V28 risk adjustment model over payment years 2024 (33%), 2025 (67%), and 2026 (100%), replacing V24. V28 consolidates HCC categories, removes some lower-acuity conditions, and recalibrates RAF weights across the entire model. For C82.58, V28 maps to Breast, Prostate, Colorectal and Other Cancers and Tumors at RAF 0.545 while V24 mapped to Lymphoma and Other Cancers at RAF 0.675. Both models can still appear in legacy data and in payer-specific lookback periods.

What should coders know when reporting C82.58?

Document which specific sites are involved to support medical necessity Ensure this code is used only when lymph nodes in 2 or more distinct regions are affected Because C82.58 maps to a payment HCC, the documentation must also satisfy MEAT criteria (Monitor, Evaluate, Assess, or Treat) for the encounter to count toward the patient's risk adjustment score.

C82.58: Diffuse follicle center lymphoma, lymph nodes of multiple sites — ICD-10 | Breast

ICD-10-CM Code View

HCC Buddy Code Card

Digital ICD-10 code-book layout with official code detail, always-visible risk models, Code Trumping, and Buddy coding guidance.

Code lookupC82.58Effective periodFY2026 Apr Update (Apr 1-Sep 30)

FY 2026 Apr update / Neoplasms (C00-D49) / Malignant neoplasms of lymphoid, hematopoietic and related tissue (C81-C96)

C82.58

Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidance

Diffuse follicle center lymphoma, lymph nodes of multiple sites

A type of non-Hodgkin lymphoma affecting follicle center cells that involves lymph nodes in multiple different body locations.

Buddy Insight

Diffuse follicle center lymphoma involving lymph nodes at multiple sites represents disseminated nodal disease that is typically stage III or IV.

CMS-HCC V28

Mapped

HCC 21

Breast, Prostate, Colorectal ...

RAF 0.545

CMS-HCC V24

Mapped

HCC 10

Lymphoma and Other Cancers

RAF 0.675

ACA/HHS

Not risk-adjusted for this model/period.

RAF 0

ESRD/PACE

Mapped

HCC 10

Lymphoma and Other Cancers

RAF 0.0

RXHCC

Mapped

HCC 21

Hodgkin Lymphoma and Other Ca...

RAF 0.0

Code Trumping

Basket needed

Compare selected patient codes to show trumped or trumps impact.

Code Book Path

Official

C82Follicular lymphoma

C82.5Diffuse follicle center lymphoma

C82.58Diffuse follicle center lymphoma, lymph nodes of multiple sites

Inclusion Terms

Official

ICD-10-CM does not list inclusion terms for C82.58 in this effective period.

Excludes 2

Official

ICD-10-CM does not list Excludes 2 notes for C82.58 in this effective period.

Related Child Codes

Official

C82.50Diffuse follicle center lymphoma, unspecified site

C82.51Diffuse follicle center lymphoma, lymph nodes of head, face, and neck

C82.52Diffuse follicle center lymphoma, intrathoracic lymph nodes

C82.53Diffuse follicle center lymphoma, intra-abdominal lymph nodes

C82.54Diffuse follicle center lymphoma, lymph nodes of axilla and upper limb

Includes

Official

ICD-10-CM does not list Includes notes for C82.58 in this effective period.

Excludes 1

Official

ICD-10-CM does not list Excludes 1 notes for C82.58 in this effective period.

Code First

Official

ICD-10-CM does not list Code First sequencing instructions for C82.58 in this effective period.

Use Additional

Official

ICD-10-CM does not list Use Additional Code instructions for C82.58 in this effective period.

Code Also

Official

ICD-10-CM does not list Code Also instructions for C82.58 in this effective period.

Buddy Documentation Tip

HCC Buddy guidance

Pathology confirming diffuse follicle center lymphoma histology

Imaging documenting lymph node involvement in at least two distinct anatomic regions

Specification of all involved nodal regions in the medical record

Staging documentation reflecting multi-site involvement

MEAT Support

HCC Buddy guidance

Pathology confirming diffuse follicle center lymphoma histology

Imaging documenting lymph node involvement in at least two distinct anatomic regions

Specification of all involved nodal regions in the medical record

Staging documentation reflecting multi-site involvement

Audit Caution

HCC Buddy guidance

Using site-specific codes for each individual region instead of the single multi-site code C82.58

Coding as unspecified site when multiple specific sites are documented — multi-site is more specific than unspecified

Not updating the code when disease initially at a single site progresses to involve multiple sites

Confusing bilateral involvement of a single region (e.g., bilateral axillary) with multi-site involvement

Common Mistakes

HCC Buddy guidance

C82.59 — Diffuse follicle center lymphoma, extranodal and solid organ sites: Use C82.58 for multi-site nodal disease; use C82.59 when non-lymph node organs are involved

C82.88 — Other types of follicular lymphoma, lymph nodes of multiple sites: Use C82.58 when pathology specifically identifies diffuse follicle center type

C82.50 — Diffuse follicle center lymphoma, unspecified site: Use C82.58 when multiple sites are documented, not the unspecified code

Last updated: FY2026 ICD-10-CM Apr update, Apr 1, 2026 through Sep 30, 2026. CMS-HCC V28 is 100% phased in for payment year 2026.

Is C82.58 an HCC code?

Yes. C82.58 maps to Breast, Prostate, Colorectal and Other Cancers and Tumors under the CMS-HCC V28 risk adjustment model (and Lymphoma and Other Cancers under V24).

HCC Category Mapping

V28HCC 21, Breast, Prostate, Colorectal and Other Cancers and Tumors

0.545

V24HCC 10, Lymphoma and Other Cancers

0.675

ESRDHCC 10, Lymphoma and Other Cancers

0.000

RxHCCHCC 21, Hodgkin Lymphoma and Other Cancers

0.000

RAF weights shown are the community, non-dual, aged base weights from the CMS risk adjustment model file. Actual per-patient RAF contribution depends on member segment, interactions, and the model year used by the payer. V28 is the CMS-HCC model phased in over payment years 2024–2026; V24 remains in use during the transition and for historical data.

Work C82.58 in the Code Book — tabular path, V28 RAF, and MEAT checklist →

MEAT Criteria for C82.58

For C82.58to count as a valid HCC diagnosis in a given encounter, the provider's documentation must show MEAT: Monitor, Evaluate, Assess, or Treat. A diagnosis from a prior year does not carry forward automatically, it has to be re-documented and supported each calendar year.

MMonitor: signs, symptoms, disease progression, or lab trending documented in the note
EEvaluate: test results, medication response, or physical findings reviewed by the provider
AAssess: explicit mention in the assessment or plan with acknowledgment of status
TTreat: medication, referral, procedure, therapy, or counseling tied to the diagnosis

Only one of M/E/A/T is required to support the code, but the documentation must be specific enough to show that the provider actually addressed C82.58 during that encounter, not just copy-forwarded from a problem list.

Coder workflow notes

Get the V28 RAF + MEAT cheat sheet

One printable page: confirm a code's V28 HCC status, its RAF weight, and the MEAT your note needs to make it stick. Free, no card.

Free PDF. No card. Unsubscribe anytime.

What This Code Means

C82.58 is the ICD-10-CM diagnosis code for diffuse follicle center lymphoma, lymph nodes of multiple sites. A type of non-Hodgkin lymphoma affecting follicle center cells that involves lymph nodes in multiple different body locations. C82.58 sits in the ICD-10-CM chapter for neoplasms (c00-d49), within the section covering malignant neoplasms of lymphoid, hematopoietic and related tissue (c81-c96).

Under the CMS-HCC V28 risk adjustment model, C82.58 maps to Breast, Prostate, Colorectal and Other Cancers and Tumors (HCC 21) with a community, non-dual, aged base RAF weight of 0.545. Under the older CMS-HCC V24 model, C82.58 maps to Lymphoma and Other Cancers (HCC 10) with a community, non-dual, aged base RAF weight of 0.675. V28 is the CMS-HCC risk adjustment model that reached 100% phase-in for payment year 2026, replacing V24 which was used during the PY2024–PY2025 transition.

Document which specific sites are involved to support medical necessity. Because C82.58 maps to a payment HCC, the provider's documentation must satisfy MEAT criteria (Monitor, Evaluate, Assess, or Treat) for the encounter to count toward the patient's Medicare Advantage risk adjustment score. When documentation is ambiguous, coders should issue a provider query rather than assume the highest-specificity variant.

HCC Buddy maintains structured V28 and V24 mapping, RAF weights, and MEAT documentation criteria for C82.58 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.

Coding Tips

•Document which specific sites are involved to support medical necessity
•Ensure this code is used only when lymph nodes in 2 or more distinct regions are affected

Clinical Significance

Diffuse follicle center lymphoma involving lymph nodes at multiple sites represents disseminated nodal disease that is typically stage III or IV. Multi-site involvement implies systemic disease requiring systemic therapy rather than localized approaches. The diffuse growth pattern combined with widespread distribution suggests this is a more aggressive presentation than typical indolent follicular lymphoma, warranting closer monitoring and potentially earlier treatment initiation.

Documentation Requirements

✓Pathology confirming diffuse follicle center lymphoma histology
✓Imaging documenting lymph node involvement in at least two distinct anatomic regions
✓Specification of all involved nodal regions in the medical record
✓Staging documentation reflecting multi-site involvement
✓Treatment plan addressing systemic disease
✓Response assessment criteria (Lugano or equivalent)

Commonly Confused Codes

•C82.59: Diffuse follicle center lymphoma, extranodal and solid organ sites: Use C82.58 for multi-site nodal disease; use C82.59 when non-lymph node organs are involved
•C82.88: Other types of follicular lymphoma, lymph nodes of multiple sites: Use C82.58 when pathology specifically identifies diffuse follicle center type
•C82.50: Diffuse follicle center lymphoma, unspecified site: Use C82.58 when multiple sites are documented, not the unspecified code