C82.57
BillableDiffuse follicle center lymphoma, spleen
Last updated: FY2026 ICD-10-CM (Oct 1, 2025 – Sep 30, 2026) | CMS-HCC V28 (100% phase-in, PY2026)
Is C82.57 an HCC code?
Yes. C82.57 maps to Breast, Prostate, Colorectal and Other Cancers and Tumors under the CMS-HCC V28 risk adjustment model (and Lymphoma and Other Cancers under V24).
HCC Category Mapping
RAF weights shown are the community, non-dual, aged base weights from the CMS risk adjustment model file. Actual per-patient RAF contribution depends on member segment, interactions, and the model year used by the payer. V28 is the CMS-HCC model phased in over payment years 2024–2026; V24 remains in use during the transition and for historical data.
MEAT Criteria for C82.57
For C82.57 to count as a valid HCC diagnosis in a given encounter, the provider's documentation must show MEAT: Monitor, Evaluate, Assess, or Treat. A diagnosis from a prior year does not carry forward automatically — it has to be re-documented and supported each calendar year.
- MMonitor: signs, symptoms, disease progression, or lab trending documented in the note
- EEvaluate: test results, medication response, or physical findings reviewed by the provider
- AAssess: explicit mention in the assessment or plan with acknowledgment of status
- TTreat: medication, referral, procedure, therapy, or counseling tied to the diagnosis
Only one of M/E/A/T is required to support the code, but the documentation must be specific enough to show that the provider actually addressed C82.57 during that encounter — not just copy-forwarded from a problem list.
What This Code Means
C82.57 is the ICD-10-CM diagnosis code for diffuse follicle center lymphoma, spleen. This is a type of cancer that starts in the lymph cells of the spleen, specifically in the follicle center cells. It's a slow-growing lymphoma that affects the spleen as the primary site of disease. C82.57 sits in the ICD-10-CM chapter for neoplasms (c00-d49), within the section covering malignant neoplasms of lymphoid, hematopoietic and related tissue (c81-c96).
Under the CMS-HCC V28 risk adjustment model, C82.57 maps to Breast, Prostate, Colorectal and Other Cancers and Tumors (HCC 21) with a community, non-dual, aged base RAF weight of 0.545. Under the older CMS-HCC V24 model, C82.57 maps to Lymphoma and Other Cancers (HCC 10) with a community, non-dual, aged base RAF weight of 0.675. V28 is the CMS-HCC risk adjustment model that reached 100% phase-in for payment year 2026, replacing V24 which was used during the PY2024–PY2025 transition.
Verify documentation specifies the spleen as the involved site; the '57' indicates spleen involvement, so ensure imaging or pathology confirms splenic involvement. Because C82.57 maps to a payment HCC, the provider's documentation must satisfy MEAT criteria (Monitor, Evaluate, Assess, or Treat) for the encounter to count toward the patient's Medicare Advantage risk adjustment score. When documentation is ambiguous, coders should issue a provider query rather than assume the highest-specificity variant.
HCC Buddy maintains structured V28 and V24 mapping, RAF weights, and MEAT documentation criteria for C82.57 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.
Coding Tips
- •Verify documentation specifies the spleen as the involved site; the '57' indicates spleen involvement, so ensure imaging or pathology confirms splenic involvement
- •This code represents a specific histological type (diffuse follicle center) and anatomical site (spleen), so confirm both elements are documented before assigning
Clinical Significance
Diffuse follicle center lymphoma involving the spleen may present with splenomegaly, cytopenias (particularly thrombocytopenia and anemia from hypersplenism), or left upper quadrant pain. Splenic lymphoma can be primary or part of disseminated disease. Splenic involvement typically places the disease at stage IV, which has treatment and prognostic implications. Some patients may require splenectomy for both diagnostic and therapeutic purposes.
Documentation Requirements
- ✓Pathology confirming diffuse follicle center lymphoma (from spleen biopsy or other tissue)
- ✓Imaging documenting splenomegaly with measurements (length, volume)
- ✓Documentation of cytopenias attributable to splenic disease (hypersplenism)
- ✓Assessment of whether splenic involvement is primary or part of disseminated disease
- ✓Splenectomy status if applicable
- ✓Complete blood count documenting hematologic impact
Commonly Confused Codes
- •C82.47 — Follicular lymphoma grade IIIb, spleen: Different histologic subtype; C82.57 is specifically diffuse follicle center pattern
- •C82.67 — Cutaneous follicle center lymphoma, spleen: Cutaneous type has primary skin origin
- •C82.87 — Other types of follicular lymphoma, spleen: Use C82.57 when diffuse follicle center type is confirmed on pathology