C82.57

HCC Category Mapping

What This Code Means

This is a type of cancer that starts in the lymph cells of the spleen, specifically in the follicle center cells. It's a slow-growing lymphoma that affects the spleen as the primary site of disease.

Coding Tips

• •Verify documentation specifies the spleen as the involved site; the '57' indicates spleen involvement, so ensure imaging or pathology confirms splenic involvement
• •This code represents a specific histological type (diffuse follicle center) and anatomical site (spleen), so confirm both elements are documented before assigning

Clinical Significance

Diffuse follicle center lymphoma involving the spleen may present with splenomegaly, cytopenias (particularly thrombocytopenia and anemia from hypersplenism), or left upper quadrant pain. Splenic lymphoma can be primary or part of disseminated disease. Splenic involvement typically places the disease at stage IV, which has treatment and prognostic implications. Some patients may require splenectomy for both diagnostic and therapeutic purposes.

Documentation Requirements

• ✓Pathology confirming diffuse follicle center lymphoma (from spleen biopsy or other tissue)
• ✓Imaging documenting splenomegaly with measurements (length, volume)
• ✓Documentation of cytopenias attributable to splenic disease (hypersplenism)
• ✓Assessment of whether splenic involvement is primary or part of disseminated disease
• ✓Splenectomy status if applicable
• ✓Complete blood count documenting hematologic impact

Commonly Confused Codes