C82.28
BillableFollicular lymphoma grade III, unspecified, lymph nodes of multiple sites
HCC Category Mapping
V28HCC 21 — Breast, Prostate, Colorectal and Other Cancers and Tumors
0.545V24HCC 10 — Lymphoma and Other Cancers
0.675ESRDHCC 10 — Lymphoma and Other Cancers
0.000RxHCCHCC 21 — Hodgkin Lymphoma and Other Cancers
0.000What This Code Means
A type of blood cancer (follicular lymphoma) affecting multiple lymph node sites throughout the body. This is an advanced grade (grade III) of the disease.
Coding Tips
- •Use this code only when lymph nodes in multiple anatomical regions are involved
- •Document which specific regions are affected for clinical clarity
Clinical Significance
Follicular lymphoma grade III unspecified involving multiple lymph node sites indicates disseminated high-grade disease. Grade III with widespread involvement is managed aggressively with chemoimmunotherapy regimens such as R-CHOP or R-CVP. This presentation carries a higher risk of transformation and requires close surveillance.
Documentation Requirements
- ✓Pathology confirming grade III follicular lymphoma
- ✓PET/CT documenting all involved lymph node regions
- ✓List of all involved anatomic sites
- ✓FLIPI score and performance status
- ✓Query for IIIa vs. IIIb subtype from pathology
Commonly Confused Codes
C82.21-C82.27 — Single-site grade III codes; use C82.28 only for multi-regional involvementC82.29 — Extranodal sites; for organ involvement, not multi-site nodal diseaseC82.18 — Grade II, multiple sites; verify grade before selectingC83.38 — Diffuse large B-cell lymphoma, multiple sites; distinct entity requiring different coding
Code Hierarchy
└C82Follicular lymphoma└C82.2Follicular lymphoma grade III, unspecified└C82.28Follicular lymphoma grade III, unspecified, lymph nodes of multiple sites
└C82.28Follicular lymphoma grade III, unspecified, lymph nodes of multiple sites