C82.27

Billable

Follicular lymphoma grade III, unspecified, spleen

HCC Category Mapping

V28HCC 21 — Breast, Prostate, Colorectal and Other Cancers and Tumors

0.545

V24HCC 10 — Lymphoma and Other Cancers

0.675

ESRDHCC 10 — Lymphoma and Other Cancers

0.000

RxHCCHCC 21 — Hodgkin Lymphoma and Other Cancers

0.000

What This Code Means

A type of blood cancer (follicular lymphoma) affecting the spleen. This is an advanced grade (grade III) of the disease.

Coding Tips

•Ensure the spleen involvement is specifically documented in the diagnostic imaging or pathology
•Check for concurrent lymph node involvement which may require additional coding

Clinical Significance

Follicular lymphoma grade III unspecified involving the spleen represents high-grade disease with splenic infiltration, conferring at least stage III classification. Grade III splenic disease may cause more pronounced splenomegaly and cytopenias than lower grades. This combination typically warrants systemic chemoimmunotherapy and consideration of rituximab-containing regimens.

Documentation Requirements

✓Pathology confirming grade III follicular lymphoma
✓Imaging documenting splenic involvement with size measurements
✓Complete blood count assessing for cytopenias from hypersplenism
✓Query for IIIa vs. IIIb subtype
✓Ann Arbor stage (at least stage III) and treatment plan

Commonly Confused Codes

C82.17 — Grade II, spleen; lower grade designation C82.37 — Grade IIIa, spleen; use when pathology specifies centrocytes present C82.47 — Grade IIIb, spleen; use for centroblast-only pattern C82.23 — Grade III, intra-abdominal; splenic hilar nodes are abdominal nodal, splenic parenchyma is C82.27

Code Hierarchy

└C82Follicular lymphoma └C82.2Follicular lymphoma grade III, unspecified └C82.27Follicular lymphoma grade III, unspecified, spleen

└C82.27Follicular lymphoma grade III, unspecified, spleen