C82.18
BillableFollicular lymphoma grade II, lymph nodes of multiple sites
HCC Category Mapping
V28HCC 21 — Breast, Prostate, Colorectal and Other Cancers and Tumors
0.545V24HCC 10 — Lymphoma and Other Cancers
0.675ESRDHCC 10 — Lymphoma and Other Cancers
0.000RxHCCHCC 21 — Hodgkin Lymphoma and Other Cancers
0.000What This Code Means
A type of slow-growing blood cancer (follicular lymphoma) that is grade II and affects lymph nodes in multiple different areas of the body.
Coding Tips
- •This code indicates involvement of lymph nodes in at least two separate anatomical regions
- •Document which specific regions are involved to support medical necessity and treatment planning
Clinical Significance
Follicular lymphoma grade II involving multiple lymph node sites represents the most common presentation, as follicular lymphoma typically presents with disseminated disease. Multi-site involvement corresponds to advanced staging and reflects the systemic nature of this malignancy. Grade II with widespread nodal disease may be more likely to require active treatment than localized disease.
Documentation Requirements
- ✓Pathology confirming grade II follicular lymphoma
- ✓Comprehensive staging with PET/CT documenting all involved regions
- ✓List of all anatomic regions with lymph node involvement
- ✓FLIPI score calculation
- ✓Treatment decision documentation (watch-and-wait vs. active therapy)
Commonly Confused Codes
C82.11-C82.17 — Single-site codes; use C82.18 when two or more distinct anatomic regions are involvedC82.19 — Extranodal sites; use C82.18 for purely nodal multi-site diseaseC82.08 — Grade I, multiple sites; verify pathology gradeC82.10 — Unspecified site; do not use unspecified when multiple sites are documented
Code Hierarchy
└C82Follicular lymphoma└C82.1Follicular lymphoma grade II└C82.18Follicular lymphoma grade II, lymph nodes of multiple sites
└C82.18Follicular lymphoma grade II, lymph nodes of multiple sites