C81.78
BillableOther Hodgkin lymphoma, lymph nodes of multiple sites
HCC Category Mapping
V28HCC 21 — Breast, Prostate, Colorectal and Other Cancers and Tumors
0.545V24HCC 10 — Lymphoma and Other Cancers
0.675ESRDHCC 10 — Lymphoma and Other Cancers
0.000RxHCCHCC 21 — Hodgkin Lymphoma and Other Cancers
0.000What This Code Means
A type of Hodgkin lymphoma affecting lymph nodes in multiple different areas of the body simultaneously.
Coding Tips
- •Use this code when lymph nodes in two or more distinct regions are involved (e.g., neck and chest)
- •Do not use if only one regional area is affected; select the specific site code instead
Clinical Significance
Other Hodgkin lymphoma involving multiple lymph node sites indicates widespread disease from an uncommon histologic variant. Multi-site involvement typically corresponds to advanced Ann Arbor staging and may require more intensive treatment regimens. Documenting all involved nodal regions is important for treatment planning and response assessment.
Documentation Requirements
- ✓Pathology confirming Hodgkin lymphoma classified as 'other' subtype
- ✓Imaging documenting involvement of at least two distinct nodal regions
- ✓Enumeration of each involved nodal region
- ✓Ann Arbor staging with documentation of all sites
- ✓Treatment plan addressing multi-site disease
Commonly Confused Codes
C81.71-C81.76 — Single-site 'other' Hodgkin lymphoma codes: use C81.78 only when two or more distinct nodal regions are documentedC81.79 — Other Hodgkin lymphoma, extranodal: C81.78 covers multiple lymph node regions; C81.79 covers organ involvementC81.98 — Hodgkin lymphoma, unspecified, multiple sites: use C81.78 when pathology classifies the variant as 'other'
Code Hierarchy
└C81Hodgkin lymphoma└C81.7Other Hodgkin lymphoma└C81.78Other Hodgkin lymphoma, lymph nodes of multiple sites
└C81.78Other Hodgkin lymphoma, lymph nodes of multiple sites