C81.42
BillableLymphocyte-rich Hodgkin lymphoma, intrathoracic lymph nodes
HCC Category Mapping
V28HCC 21 — Breast, Prostate, Colorectal and Other Cancers and Tumors
0.545V24HCC 10 — Lymphoma and Other Cancers
0.675ESRDHCC 10 — Lymphoma and Other Cancers
0.000RxHCCHCC 21 — Hodgkin Lymphoma and Other Cancers
0.000What This Code Means
A rare type of Hodgkin lymphoma (lymphocyte-rich variant) affecting lymph nodes in the chest area.
Coding Tips
- •Verify the intrathoracic location is documented in the pathology or imaging reports
- •Ensure the histological subtype is confirmed as lymphocyte-rich variant
Clinical Significance
Lymphocyte-rich Hodgkin lymphoma involving intrathoracic lymph nodes represents a favorable-prognosis subtype in a mediastinal location more commonly associated with nodular sclerosis. While less typical for lymphocyte-rich histology, intrathoracic presentation may cause mass effect symptoms. The favorable biology of this subtype generally predicts good treatment response with standard chemotherapy regimens.
Documentation Requirements
- ✓Pathology confirming lymphocyte-rich Hodgkin lymphoma histology
- ✓Chest imaging documenting intrathoracic lymph node involvement with specific station identification
- ✓Assessment for bulky disease (greater than 10 cm or one-third of chest diameter)
- ✓Ann Arbor staging
- ✓Treatment response assessment and ongoing management plan
Commonly Confused Codes
C81.12 — Nodular sclerosis Hodgkin lymphoma, intrathoracic: nodular sclerosis is much more common in the mediastinum; confirm the lymphocyte-rich subtype on pathologyC81.32 — Lymphocyte depleted Hodgkin lymphoma, intrathoracic: dramatically different prognosis; pathology distinction is essentialC85.22 — Mediastinal large B-cell lymphoma, intrathoracic: a non-Hodgkin entity that is distinct from Hodgkin lymphoma
Code Hierarchy
└C81Hodgkin lymphoma└C81.4Lymphocyte-rich Hodgkin lymphoma└C81.42Lymphocyte-rich Hodgkin lymphoma, intrathoracic lymph nodes
└C81.42Lymphocyte-rich Hodgkin lymphoma, intrathoracic lymph nodes