C81.38

HCC Category Mapping

What This Code Means

This is a type of Hodgkin lymphoma (a cancer of the lymph system) where there are very few lymphocytes (a type of white blood cell) present, and the cancer is found in lymph nodes in multiple locations throughout the body. This is a rare and aggressive form of Hodgkin lymphoma.

Coding Tips

• •The sixth character '3' indicates lymphocyte-depleted type; ensure you have confirmed this histological subtype from the pathology report before coding
• •The seventh character '8' specifies multiple lymph node sites; verify documentation clearly states involvement of multiple nodal regions (not just one area) to justify this code selection

Clinical Significance

Lymphocyte depleted Hodgkin lymphoma affecting multiple lymph node sites represents widespread dissemination of the most aggressive classical Hodgkin subtype. Multi-site involvement combined with the poor prognostic histology typically requires the most intensive available treatment regimens, often including escalated BEACOPP or consideration for clinical trial enrollment. Resource utilization is extremely high.

Documentation Requirements

• ✓Pathology confirming lymphocyte depleted Hodgkin lymphoma from at least one biopsy site
• ✓Imaging documenting involvement of at least two distinct lymph node regions
• ✓Specific identification of all involved nodal regions
• ✓Ann Arbor staging reflecting multi-site nodal involvement
• ✓Active treatment documentation or surveillance plan

Commonly Confused Codes