C81.35
BillableLymphocyte depleted Hodgkin lymphoma, lymph nodes of inguinal region and lower limb
HCC Category Mapping
V28HCC 21 — Breast, Prostate, Colorectal and Other Cancers and Tumors
0.545V24HCC 10 — Lymphoma and Other Cancers
0.675ESRDHCC 10 — Lymphoma and Other Cancers
0.000RxHCCHCC 21 — Hodgkin Lymphoma and Other Cancers
0.000What This Code Means
A rare type of Hodgkin lymphoma (lymphocyte depleted variant) affecting lymph nodes in the groin and lower legs.
Coding Tips
- •Verify documentation indicates inguinal region or lower limb lymph node involvement
- •Note any bilateral involvement in the clinical record for treatment planning purposes
Clinical Significance
Lymphocyte depleted Hodgkin lymphoma involving inguinal and lower limb lymph nodes is a very rare presentation, as this aggressive subtype more commonly involves central or abdominal nodes. Inguinal lymph node involvement may signal infradiaphragmatic disease requiring thorough staging to rule out additional sites. Treatment follows standard aggressive chemotherapy protocols.
Documentation Requirements
- ✓Pathology confirming lymphocyte depleted Hodgkin lymphoma histology
- ✓Physical exam or imaging confirming inguinal or lower limb lymph node involvement
- ✓Documentation of unilateral versus bilateral involvement
- ✓Complete staging workup to identify any additional sites of disease
- ✓Active management or monitoring documented during the encounter
Commonly Confused Codes
C81.36 — Lymphocyte depleted Hodgkin lymphoma, intrapelvic: inguinal nodes are superficial groin nodes; intrapelvic nodes are deeper within the pelvic cavityC81.25 — Mixed cellularity Hodgkin lymphoma, inguinal/lower limb: same site but different histologic subtypeC83.35 — Diffuse large B-cell lymphoma, inguinal/lower limb: non-Hodgkin lymphoma requiring pathologic distinction
Code Hierarchy
└C81Hodgkin lymphoma└C81.3Lymphocyte depleted Hodgkin lymphoma└C81.35Lymphocyte depleted Hodgkin lymphoma, lymph nodes of inguinal region and lower limb
└C81.35Lymphocyte depleted Hodgkin lymphoma, lymph nodes of inguinal region and lower limb