C81.29
BillableMixed cellularity Hodgkin lymphoma, extranodal and solid organ sites
HCC Category Mapping
V28HCC 21 — Breast, Prostate, Colorectal and Other Cancers and Tumors
0.545V24HCC 10 — Lymphoma and Other Cancers
0.675ESRDHCC 10 — Lymphoma and Other Cancers
0.000RxHCCHCC 21 — Hodgkin Lymphoma and Other Cancers
0.000What This Code Means
A type of Hodgkin lymphoma with mixed cellularity affecting organs or tissues outside the lymph node system.
Coding Tips
- •Specify which extranodal or solid organ sites are involved (liver, lungs, bone, etc.)
- •Extranodal involvement typically indicates more advanced disease
Clinical Significance
Mixed cellularity Hodgkin lymphoma with extranodal and solid organ involvement represents advanced disease that has spread beyond the lymph node system to organs such as the liver, lungs, bone marrow, or bone. This typically indicates stage IV disease requiring intensive multi-agent chemotherapy. The extranodal spread significantly impacts prognosis and treatment planning.
Documentation Requirements
- ✓Pathology confirming mixed cellularity Hodgkin lymphoma histology
- ✓Documentation of specific extranodal organ(s) involved (e.g., liver, lung, bone, bone marrow, skin)
- ✓Imaging or biopsy confirmation of extranodal spread — clinical suspicion alone is insufficient
- ✓Ann Arbor stage IV designation with specific extranodal sites documented
- ✓Active treatment plan or ongoing monitoring documentation for the encounter
Commonly Confused Codes
C81.27 — Mixed cellularity Hodgkin lymphoma, spleen: splenic involvement has its own specific code; do not use C81.29 for isolated splenic diseaseC81.28 — Mixed cellularity Hodgkin lymphoma, multiple lymph node sites: C81.28 covers multiple nodal regions while C81.29 specifically addresses non-nodal organ involvementC81.20 — Mixed cellularity Hodgkin lymphoma, unspecified: when the extranodal site is documented, C81.29 is more specific and preferred
Code Hierarchy
└C81Hodgkin lymphoma└C81.2Mixed cellularity Hodgkin lymphoma└C81.29Mixed cellularity Hodgkin lymphoma, extranodal and solid organ sites
└C81.29Mixed cellularity Hodgkin lymphoma, extranodal and solid organ sites