C81.25
BillableMixed cellularity Hodgkin lymphoma, lymph nodes of inguinal region and lower limb
HCC Category Mapping
V28HCC 21 — Breast, Prostate, Colorectal and Other Cancers and Tumors
0.545V24HCC 10 — Lymphoma and Other Cancers
0.675ESRDHCC 10 — Lymphoma and Other Cancers
0.000RxHCCHCC 21 — Hodgkin Lymphoma and Other Cancers
0.000What This Code Means
A type of Hodgkin lymphoma with mixed cellularity affecting lymph nodes in the groin and lower leg areas.
Coding Tips
- •Confirm involvement is in inguinal region and/or lower limb lymph nodes
- •Document whether one or both lower extremities are affected for clinical clarity
Clinical Significance
Mixed cellularity Hodgkin lymphoma of inguinal and lower limb lymph nodes indicates involvement of groin and lower extremity lymph nodes. This is a less common presentation site for Hodgkin lymphoma overall but may be seen more frequently in mixed cellularity compared to nodular sclerosis. Inguinal lymphadenopathy from Hodgkin lymphoma must be distinguished from reactive causes, infections, and other lymphoma subtypes that commonly present in the groin.
Documentation Requirements
- ✓Pathology confirming mixed cellularity subtype
- ✓Physical exam and imaging documenting inguinal and/or lower limb lymph node involvement
- ✓Laterality documented
- ✓Distinction from intrapelvic nodes (deep pelvis vs superficial groin)
- ✓Complete staging workup
- ✓Treatment plan
Commonly Confused Codes
C81.15 — Nodular sclerosis, inguinal/lower limb: Different subtype at the same locationC81.05 — NLPHL, inguinal/lower limb: Different subtypeC81.26 — Mixed cellularity, intrapelvic: Deep pelvic nodes vs superficial inguinal nodesC81.20 — Mixed cellularity, unspecified site: Use C81.25 when inguinal involvement is documented
Code Hierarchy
└C81Hodgkin lymphoma└C81.2Mixed cellularity Hodgkin lymphoma└C81.25Mixed cellularity Hodgkin lymphoma, lymph nodes of inguinal region and lower limb
└C81.25Mixed cellularity Hodgkin lymphoma, lymph nodes of inguinal region and lower limb