C81.22
BillableMixed cellularity Hodgkin lymphoma, intrathoracic lymph nodes
HCC Category Mapping
V28HCC 21 — Breast, Prostate, Colorectal and Other Cancers and Tumors
0.545V24HCC 10 — Lymphoma and Other Cancers
0.675ESRDHCC 10 — Lymphoma and Other Cancers
0.000RxHCCHCC 21 — Hodgkin Lymphoma and Other Cancers
0.000What This Code Means
A type of Hodgkin lymphoma with mixed cellularity affecting lymph nodes in the chest area.
Coding Tips
- •Verify the specific site of involvement is documented as intrathoracic (chest) lymph nodes
- •Confirm the histological type is mixed cellularity and not another Hodgkin lymphoma subtype
Clinical Significance
Mixed cellularity Hodgkin lymphoma of intrathoracic lymph nodes represents mediastinal or other chest lymph node involvement by this subtype. While intrathoracic involvement is the hallmark of nodular sclerosis Hodgkin lymphoma, mixed cellularity can also present in the mediastinum, though less commonly. Distinguishing between subtypes at this location requires pathologic confirmation and has implications for prognosis and EBV association.
Documentation Requirements
- ✓Pathology confirming mixed cellularity subtype (not nodular sclerosis)
- ✓Chest imaging documenting intrathoracic lymph node involvement
- ✓Assessment for mediastinal bulk
- ✓B-symptoms assessment
- ✓Complete staging workup
- ✓Treatment plan
Commonly Confused Codes
C81.12 — Nodular sclerosis, intrathoracic: Far more common at this location; pathology must confirm mixed cellularityC81.20 — Mixed cellularity, unspecified site: Use C81.22 when intrathoracic involvement is documentedC85.22 — Mediastinal large B-cell lymphoma: Different lymphoma entity entirelyC81.02 — NLPHL, intrathoracic: Different subtype
Code Hierarchy
└C81Hodgkin lymphoma└C81.2Mixed cellularity Hodgkin lymphoma└C81.22Mixed cellularity Hodgkin lymphoma, intrathoracic lymph nodes
└C81.22Mixed cellularity Hodgkin lymphoma, intrathoracic lymph nodes