C81.17
BillableNodular sclerosis Hodgkin lymphoma, spleen
HCC Category Mapping
V28HCC 21 — Breast, Prostate, Colorectal and Other Cancers and Tumors
0.545V24HCC 10 — Lymphoma and Other Cancers
0.675ESRDHCC 10 — Lymphoma and Other Cancers
0.000RxHCCHCC 21 — Hodgkin Lymphoma and Other Cancers
0.000What This Code Means
A type of Hodgkin lymphoma with nodular sclerosis pattern that has spread to the spleen.
Coding Tips
- •Character '7' specifically denotes splenic involvement; this is an important prognostic indicator
- •Requires seventh character for remission status or encounter classification
Clinical Significance
Nodular sclerosis Hodgkin lymphoma involving the spleen indicates splenic infiltration, designated with substage 'S' in the Ann Arbor staging system. Splenic involvement affects staging and prognosis and may be identified on PET/CT as focal splenic lesions or diffuse splenic enlargement. Historically, staging laparotomy with splenectomy was performed to assess splenic involvement, but modern imaging has largely replaced this approach.
Documentation Requirements
- ✓Pathology confirming nodular sclerosis subtype
- ✓Imaging (PET/CT or CT) documenting splenic involvement (focal lesions or splenomegaly with FDG uptake)
- ✓Ann Arbor stage with 'S' designation
- ✓Whether splenectomy was performed and pathology results
- ✓Treatment plan reflecting splenic involvement
- ✓Post-splenectomy vaccination documentation if applicable
Commonly Confused Codes
C81.07 — NLPHL, spleen: Different subtype; verify pathologyC81.13 — Nodular sclerosis, intra-abdominal: Spleen has its own specific code separate from abdominal nodesC81.19 — Nodular sclerosis, extranodal/solid organ: Spleen has a specific code; do not use the general extranodal codeC81.10 — Nodular sclerosis, unspecified site: Use C81.17 when splenic involvement is confirmed
Code Hierarchy
└C81Hodgkin lymphoma└C81.1Nodular sclerosis Hodgkin lymphoma└C81.17Nodular sclerosis Hodgkin lymphoma, spleen
└C81.17Nodular sclerosis Hodgkin lymphoma, spleen