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C80.2 ICD-10-CM Code: Malignant neoplasm associated with transplanted organ

C80.2 maps to CMS-HCC V28 23. A source-labeled RAF reference is available. Confirm the documented diagnosis and applicable coding requirements. MEAT criteria · RAF Calculator · HCC Buddy coding tools

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Code lookupC80.2

FY 2026 Apr update / Neoplasms (C00-D49) / Malignant neoplasms of ill-defined, other secondary and unspecified sites (C76-C80)

C80.2

Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidance

Malignant neoplasm associated with transplanted organ

Cancer that develops in an organ that was transplanted into a patient from a donor.

Buddy the Bee presenting code insight

Buddy Insight

Malignant neoplasm associated with transplanted organ captures cancers that develop in or are directly related to organ transplantation, including donor-transmitted malignancies and post-transplant lymphoproliferative disorder (PTLD).

OverviewRisk ModelsCode BookDocumentationAuditNotesEdition comparison

CMS-HCC V28

HCC 23

Coefficient HCC 23: 0.186 (Community Non-Dual Aged (CNA))

CMS-HCC V24

Historical

Historical

Not used for CY2026 payment

ACA/HHS

HCC 012

Code-level coefficient reference

ESRD/PACE

HCC 12

Code-level coefficient reference

RXHCC

HCC 22

Code-level coefficient reference

Code Book Path

Official
C80Malignant neoplasm without specification of siteC80.2Malignant neoplasm associated with transplanted organ

Inclusion Terms

Official

No inclusion terms are included in this display for C80.2. Check the code and parent instructions in the Code Book.

Excludes 2

Official

No Excludes 2 notes are included in this display for C80.2. Check the code and parent instructions in the Code Book.

Related Codes

Official
C80.0Disseminated malignant neoplasm, unspecifiedC80.1Malignant (primary) neoplasm, unspecified

Includes

Official

No Includes notes are included in this display for C80.2. Check the code and parent instructions in the Code Book.

Excludes 1

Official
  • malignant carcinoid tumor of unspecified site (C7A.00)Inherited from C80
  • malignant neoplasm of specified multiple sites- code to each siteInherited from C80

Code First

Official
  • complication of transplanted organ (T86.-)

Use Additional

Official
  • code to identify the specific malignancy

Code Also

Official

No Code Also instructions are included in this display for C80.2. Check the code and parent instructions in the Code Book.

Buddy Documentation Tip

HCC Buddy guidance
Documentation that the malignancy is associated with or arose in a transplanted organ
Type of transplant (kidney, liver, heart, lung, etc.) coded separately with Z94 codes
Specific cancer type if identifiable (code additionally if possible)
Current immunosuppression regimen and any modifications made due to the malignancy

MEAT Support

HCC Buddy guidance
Documentation that the malignancy is associated with or arose in a transplanted organ
Type of transplant (kidney, liver, heart, lung, etc.) coded separately with Z94 codes
Specific cancer type if identifiable (code additionally if possible)
Current immunosuppression regimen and any modifications made due to the malignancy

Audit Caution

HCC Buddy guidance
Failing to link the malignancy to the transplant when documentation supports the association
Not coding the transplant status (Z94 codes) as an additional diagnosis
Using C80.2 when a more specific cancer code is available — C80.2 can be used in addition to the specific cancer code
Not recognizing PTLD as a transplant-associated malignancy that may have its own specific code (D47.Z1)

Common Mistakes

HCC Buddy guidance
C80.1 — Malignant (primary) neoplasm, unspecified: Use for cancer of unknown primary without transplant association
D47.Z1 — Post-transplant lymphoproliferative disorder: Use this more specific code when PTLD is the transplant-associated malignancy
T86 series — Complications of transplanted organs: These capture organ rejection and failure, not malignancy specifically
Z94 series — Transplanted organ and tissue status: Code the transplant status separately alongside C80.2

Current with CMS: FY2026 ICD-10-CM Apr 1 update (effective Apr 1 – Sep 30, 2026) · CMS-HCC V28, 100% phased in for payment year 2026. FY2027 code set already staged for October 1, 2026. How HCC Buddy stays current →

Is C80.2 an HCC code?

Yes. C80.2 (Malignant neoplasm associated with transplanted organ) maps to HCC 23, Prostate, Breast, and Other Cancers and Tumors under the CMS-HCC V28 risk adjustment model, with a source-labeled community non-dual aged reference coefficient of 0.186. Source-labeled code-level coefficients are references, not member totals. Actual contribution depends on complete member context, hierarchy and cleanup rules, interactions, and model year. HCC Buddy's RAF Calculator supports CMS-HCC V28 PY2026 and shows no score unless every required source and calculation check passes. It is billable for payment year 2026.

Coder answer: C80.2 is billable and maps to V28 HCC 23, Prostate, Breast, and Other Cancers and Tumors. Open it in the Code Book for the tabular path, RAF, and MEAT checklist.

Code
C80.2
Description
Malignant neoplasm associated with transplanted organ
HCC (V28)
HCC 23 — Prostate, Breast, and Other Cancers and Tumors
RAF reference coefficient
0.186
Billable
Yes
Payment year
2026

HCC Category Mapping

V28HCC 23, Prostate, Breast, and Other Cancers and Tumors
0.186
ESRDHCC 12, Breast/Prostate/and Other Cancers and Tumors
Not separately weighted
RxHCCHCC 22, Prostate, Breast, Bladder, and Other Cancers and Tumors
Not separately weighted

These are source-labeled model coefficients, not member totals. A category may still be removed by hierarchy or model cleanup rules. Weights are not directly comparable across models: CMS-HCC V28 and V24 use Community, Non-Dual, Aged; ESRD uses the dialysis continuing-enrollee model; RxHCC is the Part D continuing-enrollee, non-low-income, aged weight (a larger scale than CMS-HCC). ACA/HHS has no single weight — it varies by metal level. Actual per-patient RAF contribution depends on member context, hierarchy and cleanup rules, interactions, and the model year used by the payer. V28 is the CMS-HCC model phased in over payment years 2024–2026; V24 remains available for historical review.

Work C80.2 in the Code Book — tabular path, V28 RAF reference, and MEAT checklist →

MEAT review for C80.2

For C80.2, confirm that the documentation supports the diagnosis and meets the applicable coding, encounter, program and payer requirements. MEAT (Monitor, Evaluate, Assess, or Treat) is a review mnemonic, not a universal CMS coding rule.

  • MMonitor: signs, symptoms, disease progression, or lab trending documented in the note
  • EEvaluate: test results, medication response, or physical findings reviewed by the provider
  • AAssess: explicit mention in the assessment or plan with acknowledgment of status
  • TTreat: medication, referral, procedure, therapy, or counseling tied to the diagnosis

Coder workflow notes

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What This Code Means

C80.2 is the ICD-10-CM diagnosis code for malignant neoplasm associated with transplanted organ. Cancer that develops in an organ that was transplanted into a patient from a donor. C80.2 sits in the ICD-10-CM chapter for neoplasms (c00-d49), within the section covering malignant neoplasms of ill-defined, other secondary and unspecified sites (c76-c80).

Under the CMS-HCC V28 risk adjustment model, C80.2 maps to Prostate, Breast, and Other Cancers and Tumors (HCC 23) with a source-labeled community, non-dual, aged reference coefficient of 0.186. No V24 mapping is shown for C80.2; use the applicable model and payment year when reviewing the V28 mapping. For CY2026 non-PACE Medicare Advantage, CMS uses 100% of the 2024 CMS-HCC model (V28). PACE uses a separate model blend. Source-labeled code-level coefficients are references, not member totals. Actual contribution depends on complete member context, hierarchy and cleanup rules, interactions, and model year. HCC Buddy's RAF Calculator supports CMS-HCC V28 PY2026 and shows no score unless every required source and calculation check passes.

Document the type of transplanted organ and the cancer type when possible. For C80.2, confirm that the documentation supports the diagnosis and meets the applicable coding, encounter, program and payer requirements. MEAT (Monitor, Evaluate, Assess, or Treat) is a review mnemonic, not a universal CMS coding rule. When documentation is ambiguous, coders should issue a provider query rather than assume the highest-specificity variant.

HCC Buddy maintains structured V28 and V24 mapping, source-labeled coefficient references, and MEAT documentation criteria for C80.2 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.

Coding Tips

  • •Document the type of transplanted organ and the cancer type when possible
  • •This code indicates post-transplant malignancy; coordinate with transplant history in medical record

Clinical Significance

Malignant neoplasm associated with transplanted organ captures cancers that develop in or are directly related to organ transplantation, including donor-transmitted malignancies and post-transplant lymphoproliferative disorder (PTLD). Transplant recipients have a 2-4 fold increased cancer risk due to chronic immunosuppression, and these malignancies often behave more aggressively. This diagnosis requires careful coordination between oncology and transplant teams regarding immunosuppression management.

Documentation Requirements

  • ✓Documentation that the malignancy is associated with or arose in a transplanted organ
  • ✓Type of transplant (kidney, liver, heart, lung, etc.) coded separately with Z94 codes
  • ✓Specific cancer type if identifiable (code additionally if possible)
  • ✓Current immunosuppression regimen and any modifications made due to the malignancy
  • ✓Whether the cancer was donor-transmitted or developed de novo post-transplant
  • ✓Duration since transplant to cancer diagnosis

Use Additional Code

  • code to identify the specific malignancy

Code First

  • complication of transplanted organ (T86.-)

Commonly Confused Codes

  • •C80.1: Malignant (primary) neoplasm, unspecified: Use for cancer of unknown primary without transplant association
  • •D47.Z1: Post-transplant lymphoproliferative disorder: Use this more specific code when PTLD is the transplant-associated malignancy
  • •T86 series: Complications of transplanted organs: These capture organ rejection and failure, not malignancy specifically
  • •Z94 series: Transplanted organ and tissue status: Code the transplant status separately alongside C80.2

Child Codes

C80.0Disseminated malignant neoplasm, unspecified
HCC 18
C80.1Malignant (primary) neoplasm, unspecified
HCC 23
C80.2Malignant neoplasm associated with transplanted organ
HCC 23

Code Hierarchy

└C80Malignant neoplasm without specification of site└C80.2Malignant neoplasm associated with transplanted organ
└C80.2Malignant neoplasm associated with transplanted organ

Also searched as

  • C80 2
  • C802

For C80.2, confirm that the documentation supports the diagnosis and meets the applicable coding, encounter, program and payer requirements. MEAT (Monitor, Evaluate, Assess, or Treat) is a review mnemonic, not a universal CMS coding rule.

C80.2 maps to CMS-HCC V28 category 23, Prostate, Breast, and Other Cancers and Tumors. See the ICD-10 to HCC mapping hub for how the V28 crosswalk works. The mapping identifies a payment HCC category for C80.2. Review its source-labeled HCC coefficient above, check the RAF Calculator with complete member context for CMS-HCC V28 PY2026, and confirm the documentation the chart needs before the code is submitted. HCC Buddy shows no RAF score unless every required source and calculation check passes.

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