C80.2

Billable

Malignant neoplasm associated with transplanted organ

HCC Category Mapping

V28HCC 23 — Melanoma and Other Skin Cancers

0.251

V24HCC 12 — Breast, Prostate, and Other Cancers and Tumors

0.150

ESRDHCC 12 — Breast, Prostate, and Other Cancers and Tumors

0.000

RxHCCHCC 22 — Cancer, Other Specified Sites

0.000

What This Code Means

Cancer that develops in an organ that was transplanted into a patient from a donor.

Coding Tips

•Document the type of transplanted organ and the cancer type when possible
•This code indicates post-transplant malignancy; coordinate with transplant history in medical record

Clinical Significance

Malignant neoplasm associated with transplanted organ captures cancers that develop in or are directly related to organ transplantation, including donor-transmitted malignancies and post-transplant lymphoproliferative disorder (PTLD). Transplant recipients have a 2-4 fold increased cancer risk due to chronic immunosuppression, and these malignancies often behave more aggressively. This diagnosis requires careful coordination between oncology and transplant teams regarding immunosuppression management.

Documentation Requirements

✓Documentation that the malignancy is associated with or arose in a transplanted organ
✓Type of transplant (kidney, liver, heart, lung, etc.) coded separately with Z94 codes
✓Specific cancer type if identifiable (code additionally if possible)
✓Current immunosuppression regimen and any modifications made due to the malignancy
✓Whether the cancer was donor-transmitted or developed de novo post-transplant
✓Duration since transplant to cancer diagnosis

Use Additional Code

code to identify the specific malignancy

Code First

complication of transplanted organ (T86.-)

Commonly Confused Codes

C80.1 — Malignant (primary) neoplasm, unspecified: Use for cancer of unknown primary without transplant association D47.Z1 — Post-transplant lymphoproliferative disorder: Use this more specific code when PTLD is the transplant-associated malignancy T86 series — Complications of transplanted organs: These capture organ rejection and failure, not malignancy specifically Z94 series — Transplanted organ and tissue status: Code the transplant status separately alongside C80.2

Code Hierarchy

└C80Malignant neoplasm without specification of site └C80.2Malignant neoplasm associated with transplanted organ

└C80.2Malignant neoplasm associated with transplanted organ