C75.0
BillableMalignant neoplasm of parathyroid gland
HCC Category Mapping
V28HCC 23 — Melanoma and Other Skin Cancers
0.251V24HCC 12 — Breast, Prostate, and Other Cancers and Tumors
0.150ESRDHCC 12 — Breast, Prostate, and Other Cancers and Tumors
0.000RxHCCHCC 22 — Cancer, Other Specified Sites
0.000What This Code Means
Cancer that develops in the parathyroid glands, four small glands in the neck that regulate calcium levels in the blood.
Coding Tips
- •Parathyroid carcinoma is rare; ensure documentation confirms malignancy and not benign parathyroid adenoma (which would be coded differently)
- •Verify whether single or multiple parathyroid glands are involved, as this may affect staging and treatment decisions
Clinical Significance
Malignant neoplasm of the parathyroid gland is an exceedingly rare endocrine malignancy that typically presents with severe primary hyperparathyroidism and markedly elevated calcium and parathyroid hormone levels. Parathyroid carcinoma accounts for less than 1% of primary hyperparathyroidism cases, making accurate diagnosis and coding critical for treatment planning and surveillance.
Documentation Requirements
- ✓Pathology confirming parathyroid carcinoma — histological diagnosis is challenging and often requires expert review
- ✓Calcium and parathyroid hormone levels (typically markedly elevated in carcinoma vs. adenoma)
- ✓Documentation distinguishing from parathyroid adenoma (benign) which is far more common
- ✓Staging and extent of disease including any lymph node or distant metastases
- ✓Treatment status (surgical resection, monitoring of calcium levels)
Commonly Confused Codes
D35.1 — Benign neoplasm of parathyroid gland: Parathyroid adenomas are benign and much more commonE21.0 — Primary hyperparathyroidism: Hormonal condition caused by the tumor; code both when applicableE83.52 — Hypercalcemia: A manifestation of the parathyroid malignancy; code additionally when documentedC73 — Malignant neoplasm of thyroid gland: Adjacent anatomy; verify parathyroid vs. thyroid originD44.2 — Neoplasm of uncertain behavior of parathyroid gland: Use when malignancy is not confirmed
Code Hierarchy
└C75Malignant neoplasm of other endocrine glands and related structures└C75.0Malignant neoplasm of parathyroid gland
└C75.0Malignant neoplasm of parathyroid gland