C54.2
BillableMalignant neoplasm of myometrium
HCC Category Mapping
V28HCC 23 — Melanoma and Other Skin Cancers
0.251V24HCC 12 — Breast, Prostate, and Other Cancers and Tumors
0.150ESRDHCC 12 — Breast, Prostate, and Other Cancers and Tumors
0.000What This Code Means
Cancer that develops in the myometrium, which is the muscular layer of the uterus. This is a less common type of uterine cancer.
Coding Tips
- •Distinguish between myometrial sarcomas and carcinomas, as treatment differs significantly
- •Ensure documentation specifies myometrium involvement rather than endometrial involvement
Clinical Significance
Malignant neoplasm of the myometrium represents cancer originating in the muscular wall of the uterus. Myometrial malignancies are typically sarcomas (leiomyosarcoma, endometrial stromal sarcoma) rather than carcinomas, making them clinically distinct from the more common endometrial cancers. These tumors tend to be more aggressive with different treatment protocols.
Documentation Requirements
- ✓Specific site confirmed as myometrium (muscular layer)
- ✓Histological type (leiomyosarcoma, endometrial stromal sarcoma, undifferentiated sarcoma)
- ✓Differentiation from endometrial carcinoma invading the myometrium versus primary myometrial tumor
- ✓Tumor size and extent
- ✓FIGO staging
- ✓Mitotic rate (critical for distinguishing leiomyosarcoma from leiomyoma)
- ✓Lymph node and distant metastasis assessment
Commonly Confused Codes
C54.1 — Malignant neoplasm of endometrium; endometrial cancer may invade myometrium but the primary site is endometrium, not myometriumD25.1 — Intramural leiomyoma of uterus; benign uterine fibroid — must distinguish from leiomyosarcomaC54.9 — Corpus uteri, unspecified; less specific when myometrium is identifiedC54.8 — Overlapping sites of corpus uteri; use when tumor spans multiple uterine structures
Code Hierarchy
└C54Malignant neoplasm of corpus uteri└C54.2Malignant neoplasm of myometrium
└C54.2Malignant neoplasm of myometrium