C54.1

Billable

Malignant neoplasm of endometrium

HCC Category Mapping

V28HCC 23 — Melanoma and Other Skin Cancers

0.251

V24HCC 12 — Breast, Prostate, and Other Cancers and Tumors

0.150

ESRDHCC 12 — Breast, Prostate, and Other Cancers and Tumors

0.000

What This Code Means

Cancer that starts in the endometrium, which is the inner lining of the uterus. This is the most common type of uterine cancer.

Coding Tips

•Verify histology type (adenocarcinoma, sarcoma, etc.) as it may affect treatment and prognosis
•Confirm laterality is not applicable; use this code for endometrial cancers regardless of location within the uterus

Clinical Significance

Malignant neoplasm of the endometrium is the most common gynecological cancer in developed countries, with endometrioid adenocarcinoma being the predominant histological type. Risk factors include obesity, unopposed estrogen exposure, nulliparity, and tamoxifen use. Early detection through evaluation of abnormal uterine bleeding typically results in favorable outcomes.

Documentation Requirements

✓Histological type specified (endometrioid, serous, clear cell, mixed, carcinosarcoma)
✓Tumor grade (Grade 1, 2, or 3)
✓FIGO staging
✓Depth of myometrial invasion (less than or greater than 50%)
✓Cervical stromal involvement (upstages to stage II)
✓Lymphovascular space invasion
✓Lymph node status (pelvic and para-aortic)
✓Estrogen and progesterone receptor status if documented
✓Mismatch repair or microsatellite instability status if available

Commonly Confused Codes

C54.2 — Malignant neoplasm of myometrium; different uterine layer — endometrium is the inner lining, myometrium is the muscle layer C54.9 — Corpus uteri, unspecified; less specific when endometrium is clearly identified C55 — Uterus, part unspecified; use only when the specific uterine structure cannot be determined D07.0 — Carcinoma in situ of endometrium; endometrial intraepithelial neoplasia, not invasive cancer N85.0 — Endometrial hyperplasia; benign condition, not malignancy

Code Hierarchy

└C54Malignant neoplasm of corpus uteri └C54.1Malignant neoplasm of endometrium

└C54.1Malignant neoplasm of endometrium