B10.01 ICD-10-CM Code: Human herpesvirus 6 encephalitis
B10.01 is not a CMS-HCC payment code. MEAT criteria · RAF Calculator · HCC Buddy coding tools
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FY 2026 Apr update / Certain infectious and parasitic diseases (A00-B99) / Other human herpesviruses (B10)
B10.01
Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidanceHuman herpesvirus 6 encephalitis
An infection caused by human herpesvirus 6 that causes inflammation of the brain.
CMS-HCC V28
N/A—
Not mapped
CMS-HCC V24
HistoricalHistorical
Not used for CY2026 payment
ACA/HHS
MappedHCC 003
Code-level coefficient reference
ESRD/PACE
N/A—
Not mapped
RXHCC
N/A—
Not mapped
Code Book Path
Inclusion Terms
OfficialNo inclusion terms are included in this display for B10.01. Check the code and parent instructions in the Code Book.
Excludes 2
Official- carrier or suspected carrier of infectious disease (Z22.-)Inherited from A00-B99, B10, B10.0
- infectious and parasitic diseases complicating pregnancy, childbirth and the puerperium (O98.-)Inherited from A00-B99, B10, B10.0
- infectious and parasitic diseases specific to the perinatal period (P35-P39)Inherited from A00-B99, B10, B10.0
- influenza and other acute respiratory infections (J00-J22)Inherited from A00-B99, B10, B10.0
- cytomegalovirus (B25.9)Inherited from A00-B99, B10, B10.0
- Epstein-Barr virus (B27.0-)Inherited from A00-B99, B10, B10.0
- herpes NOS (B00.9)Inherited from A00-B99, B10, B10.0
- herpes simplex (B00.-)Inherited from A00-B99, B10, B10.0
- herpes zoster (B02.-)Inherited from A00-B99, B10, B10.0
- human herpesvirus NOS (B00.-)Inherited from A00-B99, B10, B10.0
- human herpesvirus 1 and 2 (B00.-)Inherited from A00-B99, B10, B10.0
- human herpesvirus 3 (B01.-, B02.-)Inherited from A00-B99, B10, B10.0
- human herpesvirus 4 (B27.0-)Inherited from A00-B99, B10, B10.0
- human herpesvirus 5 (B25.-)Inherited from A00-B99, B10, B10.0
- varicella (B01.-)Inherited from A00-B99, B10, B10.0
- zoster (B02.-)Inherited from A00-B99, B10, B10.0
- herpes encephalitis NOS (B00.4)Inherited from A00-B99, B10, B10.0
- herpes simplex encephalitis (B00.4)Inherited from A00-B99, B10, B10.0
- human herpesvirus encephalitis (B00.4)Inherited from A00-B99, B10, B10.0
- simian B herpes virus encephalitis (B00.4)Inherited from A00-B99, B10, B10.0
Related Codes
Includes
Official- diseases generally recognized as communicable or transmissibleInherited from A00-B99
Excludes 1
Official- certain localized infections - see body system-related chaptersInherited from A00-B99
Code First
OfficialNo Code First sequencing instructions are included in this display for B10.01. Check the code and parent instructions in the Code Book.
Use Additional
Official- code to identify resistance to antimicrobial drugs (Z16.-)Inherited from A00-B99
Code Also
OfficialNo Code Also instructions are included in this display for B10.01. Check the code and parent instructions in the Code Book.
Buddy Documentation Tip
Current with CMS: FY2026 ICD-10-CM Apr 1 update (effective Apr 1 – Sep 30, 2026) · CMS-HCC V28, 100% phased in for payment year 2026. FY2027 code set already staged for October 1, 2026. How HCC Buddy stays current →
Is B10.01 an HCC code?
B10.01 is not in the CMS-HCC V28 or V24 community payment model. B10.01 also appears in the HHS-HCC commercial risk model (HCC 003 (HHS-HCC 003 adult, RAF varies by metal level)), which is a commercial market model rather than a Medicare Advantage payment mapping.
- Code
- B10.01
- Description
- Human herpesvirus 6 encephalitis
- HCC (V28)
- No CMS-HCC V28 mapping
- RAF reference coefficient
- —
- Billable
- Yes
- Payment year
- 2026
Coder workflow notes
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This code does not map to an HCC category in any model (V28, V24, ESRD, RxHCC).
What This Code Means
B10.01 is the ICD-10-CM diagnosis code for human herpesvirus 6 encephalitis. An infection caused by human herpesvirus 6 that causes inflammation of the brain. B10.01 sits in the ICD-10-CM chapter for certain infectious and parasitic diseases (a00-b99), within the section covering other human herpesviruses (b10).
B10.01 has no mapping under the CMS-HCC V28 or V24 community payment models. B10.01 also appears in the HHS-HCC commercial risk model (HCC 003 (HHS-HCC 003 adult, RAF varies by metal level)), which is a commercial market model rather than a Medicare Advantage payment mapping. Do not assign V28 risk adjustment value from this page; verify the applicable model and payment year before using this code for risk adjustment.
Ensure documentation clearly states HHV-6 as the causative agent and confirms encephalitis diagnosis.
HCC Buddy maintains structured V28 and V24 mapping, source-labeled coefficient references, and MEAT documentation criteria for B10.01 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.
Coding Tips
- •Ensure documentation clearly states HHV-6 as the causative agent and confirms encephalitis diagnosis
- •This is a serious condition; verify appropriate severity documentation and any complications

