A52.10 ICD-10-CM Code: Symptomatic neurosyphilis, unspecified

A52.10 is the ICD-10-CM diagnosis code for symptomatic neurosyphilis, unspecified. This code describes syphilis that has spread to the nervous system and is causing symptoms, but the specific type of nervous system involvement has not been identified. Neurosyphilis occurs when the syphilis bacteria damages the brain, spinal cord, or nerves. A52.10 sits in the ICD-10-CM chapter for certain infectious and parasitic diseases (a00-b99), within the section covering infections with a predominantly sexual mode of transmission (a50-a64).

A52.10 is a billable ICD-10-CM code but does not map to a payment HCC under the CMS-HCC V28, V24, ESRD, or RxHCC risk adjustment models. It can be reported on Medicare Advantage encounter data submissions but it does not contribute to a beneficiary's RAF score and therefore does not affect risk-adjusted payments to the plan.

Use this code only when neurosyphilis is confirmed but the specific manifestation (such as general paresis, tabes dorsalis, or meningitis) is not documented; if a specific type is identified, use a more specific A52.1x code.