A51.45 ICD-10-CM Code: Secondary syphilitic hepatitis
HCC Buddy Code Card
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FY 2026 Apr update / Certain infectious and parasitic diseases (A00-B99) / Infections with a predominantly sexual mode of transmission (A50-A64)
A51.45
Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidanceSecondary syphilitic hepatitis
This is liver inflammation caused by syphilis that develops during the secondary stage of the infection, typically occurring weeks to months after the initial infection. It represents the body's systemic response to the syphilis bacteria affecting the liver.
CMS-HCC V28
00
RAF 0
CMS-HCC V24
00
RAF 0
ACA/HHS
00
RAF 0
ESRD/PACE
00
RAF 0
RXHCC
00
RAF 0
Code Trumping
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Code Book Path
Inclusion Terms
OfficialICD-10-CM does not list inclusion terms for A51.45 in this effective period.
Excludes 2
OfficialICD-10-CM does not list Excludes 2 notes for A51.45 in this effective period.
Related Child Codes
Includes
OfficialICD-10-CM does not list Includes notes for A51.45 in this effective period.
Excludes 1
OfficialICD-10-CM does not list Excludes 1 notes for A51.45 in this effective period.
Code First
OfficialICD-10-CM does not list Code First sequencing instructions for A51.45 in this effective period.
Use Additional
OfficialICD-10-CM does not list Use Additional Code instructions for A51.45 in this effective period.
Code Also
OfficialICD-10-CM does not list Code Also instructions for A51.45 in this effective period.
Buddy Documentation Tip
Last updated: FY2026 ICD-10-CM Apr update, Apr 1, 2026 through Sep 30, 2026. CMS-HCC V28 is 100% phased in for payment year 2026.
Is A51.45 an HCC code?
No. A51.45 is a billable ICD-10-CM code but does not map to any HCC category in V28, V24, ESRD, or RxHCC.
Coder workflow notes
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This code does not map to an HCC category in any model (V28, V24, ESRD, RxHCC).
What This Code Means
A51.45 is the ICD-10-CM diagnosis code for secondary syphilitic hepatitis. This is liver inflammation caused by syphilis that develops during the secondary stage of the infection, typically occurring weeks to months after the initial infection. It represents the body's systemic response to the syphilis bacteria affecting the liver. A51.45 sits in the ICD-10-CM chapter for certain infectious and parasitic diseases (a00-b99), within the section covering infections with a predominantly sexual mode of transmission (a50-a64).
A51.45 is a billable ICD-10-CM code but does not map to a payment HCC under the CMS-HCC V28, V24, ESRD, or RxHCC risk adjustment models. It can be reported on Medicare Advantage encounter data submissions but it does not contribute to a beneficiary's RAF score and therefore does not affect risk-adjusted payments to the plan.
Verify that the hepatitis is specifically documented as secondary syphilitic hepatitis in the medical record; do not assume liver involvement without explicit documentation.
HCC Buddy maintains structured V28 and V24 mapping, RAF weights, and MEAT documentation criteria for A51.45 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.
Coding Tips
- •Verify that the hepatitis is specifically documented as secondary syphilitic hepatitis in the medical record; do not assume liver involvement without explicit documentation
- •Ensure the primary syphilis diagnosis code (A51.x) is also coded to capture the complete clinical picture, as this code represents a manifestation of secondary syphilis