A41.2 ICD-10-CM Code: Sepsis due to unspecified staphylococcus
A41.2 maps to CMS-HCC V28 2. A source-labeled RAF reference is available. Confirm the documented diagnosis and applicable coding requirements. MEAT criteria · RAF Calculator · HCC coding software
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FY 2026 Apr update / Certain infectious and parasitic diseases (A00-B99) / Other bacterial diseases (A30-A49)
A41.2
Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidanceSepsis due to unspecified staphylococcus
A serious bloodstream infection caused by staphylococcus bacteria when the specific type of staph cannot be identified. This is a life-threatening condition where bacteria have entered the bloodstream and triggered a severe inflammatory response throughout the body.

Buddy Insight
Sepsis due to unspecified staphylococcus is used when staphylococcal bloodstream infection is documented but the specific species (aureus vs.
CMS-HCC V28
MappedHCC 2
Coefficient HCC 2: 0.500 (Community Non-Dual Aged (CNA))
CMS-HCC V24
HistoricalHistorical
Not used for CY2026 payment
ACA/HHS
MappedHCC 002
Code-level coefficient reference
ESRD/PACE
MappedHCC 2
Code-level coefficient reference
RXHCC
N/A—
Not mapped
Code Book Path
Inclusion Terms
OfficialNo inclusion terms are included in this display for A41.2. Check the code and parent instructions in the Code Book.
Excludes 2
Official- carrier or suspected carrier of infectious disease (Z22.-)Inherited from A00-B99, A41
- infectious and parasitic diseases complicating pregnancy, childbirth and the puerperium (O98.-)Inherited from A00-B99, A41
- infectious and parasitic diseases specific to the perinatal period (P35-P39)Inherited from A00-B99, A41
- influenza and other acute respiratory infections (J00-J22)Inherited from A00-B99, A41
- sepsis (due to) (in) actinomycotic (A42.7)Inherited from A00-B99, A41
- sepsis (due to) (in) anthrax (A22.7)Inherited from A00-B99, A41
- sepsis (due to) (in) candidal (B37.7)Inherited from A00-B99, A41
- sepsis (due to) (in) Erysipelothrix (A26.7)Inherited from A00-B99, A41
- sepsis (due to) (in) extraintestinal yersiniosis (A28.2)Inherited from A00-B99, A41
- sepsis (due to) (in) gonococcal (A54.86)Inherited from A00-B99, A41
- sepsis (due to) (in) herpesviral (B00.7)Inherited from A00-B99, A41
- sepsis (due to) (in) listerial (A32.7)Inherited from A00-B99, A41
- sepsis (due to) (in) melioidosis (A24.1)Inherited from A00-B99, A41
- sepsis (due to) (in) meningococcal (A39.2-A39.4)Inherited from A00-B99, A41
- sepsis (due to) (in) plague (A20.7)Inherited from A00-B99, A41
- sepsis (due to) (in) tularemia (A21.7)Inherited from A00-B99, A41
- toxic shock syndrome (A48.3)Inherited from A00-B99, A41
Related Codes
Includes
Official- diseases generally recognized as communicable or transmissibleInherited from A00-B99
Excludes 1
Official- certain localized infections - see body system-related chaptersInherited from A00-B99, A41
- bacteremia NOS (R78.81)Inherited from A00-B99, A41
- neonatal (P36.-)Inherited from A00-B99, A41
- puerperal sepsis (O85)Inherited from A00-B99, A41
- streptococcal sepsis (A40.-)Inherited from A00-B99, A41
Code First
Official- , if applicable, postprocedural sepsis (T81.44-)Inherited from A41
- sepsis due to central venous catheter (T80.211-)Inherited from A41
- sepsis during labor (O75.3)Inherited from A41
- sepsis following abortion, ectopic or molar pregnancy (O03.37, O03.87, O04.87, O07.37, O08.82)Inherited from A41
- sepsis following immunization (T88.0-)Inherited from A41
- sepsis following infusion, transfusion or therapeutic injection (T80.22-, T80.29-)Inherited from A41
Use Additional
Official- code to identify resistance to antimicrobial drugs (Z16.-)Inherited from A00-B99
Code Also
OfficialNo Code Also instructions are included in this display for A41.2. Check the code and parent instructions in the Code Book.
Buddy Documentation Tip
MEAT Support
Audit Caution
Common Mistakes
Current with CMS: FY2026 ICD-10-CM Apr 1 update (effective Apr 1 – Sep 30, 2026) · CMS-HCC V28, 100% phased in for payment year 2026. FY2027 code set already staged for October 1, 2026. How HCC Buddy stays current →
Is A41.2 an HCC code?
Yes. A41.2 (Sepsis due to unspecified staphylococcus) maps to HCC 2, Septicemia, Sepsis, Systemic Inflammatory Response Syndrome/Shock under the CMS-HCC V28 risk adjustment model, with a source-labeled community non-dual aged reference coefficient of 0.500. Source-labeled code-level coefficients are references, not member totals. Actual contribution depends on complete member context, hierarchy and cleanup rules, interactions, and model year. HCC Buddy's RAF Calculator supports CMS-HCC V28 PY2026 and shows no score unless every required source and calculation check passes. It is billable for payment year 2026.
Coder answer: A41.2 is billable and maps to V28 HCC 2, Septicemia, Sepsis, Systemic Inflammatory Response Syndrome/Shock. Open it in the Code Book for the tabular path, RAF, and MEAT checklist.
- Code
- A41.2
- Description
- Sepsis due to unspecified staphylococcus
- HCC (V28)
- HCC 2 — Septicemia, Sepsis, Systemic Inflammatory Response Syndrome/Shock
- RAF reference coefficient
- 0.500
- Billable
- Yes
- Payment year
- 2026
HCC Category Mapping
These are source-labeled model coefficients, not member totals. A category may still be removed by hierarchy or model cleanup rules. Weights are not directly comparable across models: CMS-HCC V28 and V24 use Community, Non-Dual, Aged; ESRD uses the dialysis continuing-enrollee model; RxHCC is the Part D continuing-enrollee, non-low-income, aged weight (a larger scale than CMS-HCC). ACA/HHS has no single weight — it varies by metal level. Actual per-patient RAF contribution depends on member context, hierarchy and cleanup rules, interactions, and the model year used by the payer. V28 is the CMS-HCC model phased in over payment years 2024–2026; V24 remains available for historical review.
Work A41.2 in the Code Book — tabular path, V28 RAF reference, and MEAT checklist →
MEAT review for A41.2
For A41.2, confirm that the documentation supports the diagnosis and meets the applicable coding, encounter, program and payer requirements. MEAT (Monitor, Evaluate, Assess, or Treat) is a review mnemonic, not a universal CMS coding rule.
- MMonitor: signs, symptoms, disease progression, or lab trending documented in the note
- EEvaluate: test results, medication response, or physical findings reviewed by the provider
- AAssess: explicit mention in the assessment or plan with acknowledgment of status
- TTreat: medication, referral, procedure, therapy, or counseling tied to the diagnosis
Coder workflow notes
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What This Code Means
A41.2 is the ICD-10-CM diagnosis code for sepsis due to unspecified staphylococcus. A serious bloodstream infection caused by staphylococcus bacteria when the specific type of staph cannot be identified. This is a life-threatening condition where bacteria have entered the bloodstream and triggered a severe inflammatory response throughout the body. A41.2 sits in the ICD-10-CM chapter for certain infectious and parasitic diseases (a00-b99), within the section covering other bacterial diseases (a30-a49).
Under the CMS-HCC V28 risk adjustment model, A41.2 maps to Septicemia, Sepsis, Systemic Inflammatory Response Syndrome/Shock (HCC 2) with a source-labeled community, non-dual, aged reference coefficient of 0.500. For CY2026 non-PACE Medicare Advantage, CMS uses 100% of the 2024 CMS-HCC model (V28). PACE uses a separate model blend. Source-labeled code-level coefficients are references, not member totals. Actual contribution depends on complete member context, hierarchy and cleanup rules, interactions, and model year. HCC Buddy's RAF Calculator supports CMS-HCC V28 PY2026 and shows no score unless every required source and calculation check passes.
Always attempt to obtain the specific staphylococcus organism type (aureus, epidermidis, etc.) from culture results or clinical documentation, as more specific codes (A41.0, A41.1) are preferred over the unspecified code A41.2. For A41.2, confirm that the documentation supports the diagnosis and meets the applicable coding, encounter, program and payer requirements. MEAT (Monitor, Evaluate, Assess, or Treat) is a review mnemonic, not a universal CMS coding rule. When documentation is ambiguous, coders should issue a provider query rather than assume the highest-specificity variant.
HCC Buddy maintains structured V28 and V24 mapping, source-labeled coefficient references, and MEAT documentation criteria for A41.2 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.
Coding Tips
- •Always attempt to obtain the specific staphylococcus organism type (aureus, epidermidis, etc.) from culture results or clinical documentation, as more specific codes (A41.0, A41.1) are preferred over the unspecified code A41.2
- •Sepsis codes require a secondary code to identify the source of infection when documented; review the medical record for any localized infection site that may have seeded the bloodstream
Clinical Significance
Sepsis due to unspecified staphylococcus is used when staphylococcal bloodstream infection is documented but the specific species (aureus vs. coagulase-negative) or methicillin susceptibility is not identified. This code should be a placeholder pending culture and susceptibility results rather than a final code assignment.
Documentation Requirements
- ✓Blood cultures growing Staphylococcus species without further speciation or susceptibility testing completed
- ✓Clinical sepsis criteria met
- ✓Documentation that staphylococcal species identification is pending or unavailable
- ✓Query provider for species-level identification when results become available
- ✓Clinical context suggesting staphylococcal source
Commonly Confused Codes
- •A41.01 (MSSA sepsis): Preferred when methicillin-susceptible S. aureus is confirmed
- •A41.02 (MRSA sepsis): Preferred when methicillin-resistant S. aureus is confirmed
- •A41.1 (Other specified staphylococcus): Preferred when a specific non-aureus species is identified
- •A41.9 (Sepsis, unspecified organism): A41.2 is more specific than A41.9 since it identifies the genus

