F18.21
BillableInhalant dependence, in remission
Last updated: FY2026 ICD-10-CM (Oct 1, 2025 – Sep 30, 2026) | CMS-HCC V28 (100% phase-in, PY2026)
Is F18.21 an HCC code?
Yes. F18.21 maps to Drug Use Disorder/Substance Use Disorder, Moderate/Severe under the CMS-HCC V28 risk adjustment model (and Drug/Alcohol Dependence under V24).
HCC Category Mapping
RAF weights shown are the community, non-dual, aged base weights from the CMS risk adjustment model file. Actual per-patient RAF contribution depends on member segment, interactions, and the model year used by the payer. V28 is the CMS-HCC model phased in over payment years 2024–2026; V24 remains in use during the transition and for historical data.
MEAT Criteria for F18.21
For F18.21 to count as a valid HCC diagnosis in a given encounter, the provider's documentation must show MEAT: Monitor, Evaluate, Assess, or Treat. A diagnosis from a prior year does not carry forward automatically — it has to be re-documented and supported each calendar year.
- MMonitor: signs, symptoms, disease progression, or lab trending documented in the note
- EEvaluate: test results, medication response, or physical findings reviewed by the provider
- AAssess: explicit mention in the assessment or plan with acknowledgment of status
- TTreat: medication, referral, procedure, therapy, or counseling tied to the diagnosis
Only one of M/E/A/T is required to support the code, but the documentation must be specific enough to show that the provider actually addressed F18.21 during that encounter — not just copy-forwarded from a problem list.
What This Code Means
F18.21 is the ICD-10-CM diagnosis code for inhalant dependence, in remission. A person who was dependent on inhalants but has successfully stopped using them and maintained abstinence for a sustained period. F18.21 sits in the ICD-10-CM chapter for mental, behavioral and neurodevelopmental disorders (f01-f99), within the section covering mental and behavioral disorders due to psychoactive substance use (f10-f19).
Under the CMS-HCC V28 risk adjustment model, F18.21 maps to Drug Use Disorder/Substance Use Disorder, Moderate/Severe (HCC 137) with a community, non-dual, aged base RAF weight of 0.358. Under the older CMS-HCC V24 model, F18.21 maps to Drug/Alcohol Dependence (HCC 55) with a community, non-dual, aged base RAF weight of 0.334. V28 is the CMS-HCC risk adjustment model that reached 100% phase-in for payment year 2026, replacing V24 which was used during the PY2024–PY2025 transition.
Document the length of remission when available (early vs sustained remission). Because F18.21 maps to a payment HCC, the provider's documentation must satisfy MEAT criteria (Monitor, Evaluate, Assess, or Treat) for the encounter to count toward the patient's Medicare Advantage risk adjustment score. When documentation is ambiguous, coders should issue a provider query rather than assume the highest-specificity variant.
HCC Buddy maintains structured V28 and V24 mapping, RAF weights, and MEAT documentation criteria for F18.21 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.
Coding Tips
- •Document the length of remission when available (early vs sustained remission)
- •Remission codes indicate the patient is no longer actively using despite past dependence
Clinical Significance
Inhalant dependence in remission indicates a patient who has achieved recovery from inhalant dependence. Given the severe neurotoxic effects of chronic inhalant use, residual cognitive deficits, white matter changes, and organ damage may persist even in remission, requiring ongoing monitoring and rehabilitation.
Documentation Requirements
- ✓Documentation of prior inhalant dependence
- ✓Provider statement of remission status (early vs sustained)
- ✓Duration of remission
- ✓Monitoring plan for residual neurological and organ damage
- ✓Relapse prevention plan
- ✓Neurocognitive assessment results if available
Commonly Confused Codes
- •F18.20 — Inhalant dependence, uncomplicated; use for active dependence
- •F18.11 — Inhalant abuse, in remission; use when the prior condition was abuse not dependence
- •Z86.59 — Personal history of mental and behavioral disorders; less specific, loses HCC capture
- •F18.90 — Inhalant use, unspecified; does not capture dependence or remission