E88.3 ICD-10-CM Code: Tumor lysis syndrome
E88.3 is not a CMS-HCC payment code. MEAT criteria · RAF Calculator · free HCC coding tools
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FY 2026 Apr update / Endocrine, nutritional and metabolic diseases (E00-E89) / Metabolic disorders (E70-E88)
E88.3
Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidanceTumor lysis syndrome
A serious metabolic emergency that occurs when cancer cells die rapidly, releasing their contents into the bloodstream and causing dangerous chemical imbalances.
CMS-HCC V28
N/A—
Not mapped
CMS-HCC V24
HistoricalHistorical
Not used for CY2026 payment
ACA/HHS
MappedHCC 008
Code-level coefficient reference
ESRD/PACE
N/A—
Not mapped
RXHCC
N/A—
Not mapped
Code Book Path
Inclusion Terms
Official- Tumor lysis syndrome (spontaneous)
- Tumor lysis syndrome following antineoplastic drug chemotherapy
Excludes 2
OfficialICD-10-CM does not list Excludes 2 notes for E88.3 in this effective period.
Related Child Codes
Includes
OfficialICD-10-CM does not list Includes notes for E88.3 in this effective period.
Excludes 1
Official- histiocytosis X (chronic) (C96.6)
Code First
OfficialICD-10-CM does not list Code First sequencing instructions for E88.3 in this effective period.
Use Additional
Official- code for adverse effect, if applicable, to identify drug (T45.1X5)
Code Also
OfficialICD-10-CM does not list Code Also instructions for E88.3 in this effective period.
Buddy Documentation Tip
Current with CMS: FY2026 ICD-10-CM Apr 1 update (effective Apr 1 – Sep 30, 2026) · CMS-HCC V28, 100% phased in for payment year 2026. FY2027 code set already staged for October 1, 2026. How HCC Buddy stays current →
Is E88.3 an HCC code?
E88.3 is not in the CMS-HCC V28 or V24 community payment model. E88.3 also appears in the HHS-HCC commercial risk model (HCC 008 (HHS-HCC 008 adult, RAF varies by metal level)), which is a commercial market model rather than a Medicare Advantage payment mapping.
- Code
- E88.3
- Description
- Tumor lysis syndrome
- HCC (V28)
- No CMS-HCC V28 mapping
- RAF reference coefficient
- —
- Billable
- Yes
- Payment year
- 2026
Coder workflow notes
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This code does not map to an HCC category in any model (V28, V24, ESRD, RxHCC).
What This Code Means
E88.3 is the ICD-10-CM diagnosis code for tumor lysis syndrome. A serious metabolic emergency that occurs when cancer cells die rapidly, releasing their contents into the bloodstream and causing dangerous chemical imbalances. E88.3 sits in the ICD-10-CM chapter for endocrine, nutritional and metabolic diseases (e00-e89), within the section covering metabolic disorders (e70-e88).
E88.3 has no mapping under the CMS-HCC V28 or V24 community payment models. E88.3 also appears in the HHS-HCC commercial risk model (HCC 008 (HHS-HCC 008 adult, RAF varies by metal level)), which is a commercial market model rather than a Medicare Advantage payment mapping. Do not assign V28 risk adjustment value from this page; verify the applicable model and payment year before using this code for risk adjustment.
This is typically an acute complication; code the underlying malignancy separately.
HCC Buddy maintains structured V28 and V24 mapping, source-labeled coefficient references, and MEAT documentation criteria for E88.3 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.
Coding Tips
- •This is typically an acute complication; code the underlying malignancy separately
- •Document the trigger (chemotherapy, radiation, or spontaneous tumor breakdown) and any associated acute kidney injury or electrolyte abnormalities
Use Additional Code
- code for adverse effect, if applicable, to identify drug (T45.1X5)