C82.50
BillableDiffuse follicle center lymphoma, unspecified site
HCC Category Mapping
V28HCC 21 — Breast, Prostate, Colorectal and Other Cancers and Tumors
0.545V24HCC 10 — Lymphoma and Other Cancers
0.675ESRDHCC 10 — Lymphoma and Other Cancers
0.000RxHCCHCC 21 — Hodgkin Lymphoma and Other Cancers
0.000What This Code Means
A type of cancer of the lymph system (diffuse follicle center lymphoma) at an unspecified location in the body.
Coding Tips
- •Code C82.50 should only be used when the specific anatomical site is not documented; attempt to obtain site information
- •Diffuse follicle center lymphoma is a variant of follicular lymphoma with different prognosis
Clinical Significance
Diffuse follicle center lymphoma at an unspecified site is a distinct variant of follicular lymphoma characterized by a diffuse (non-follicular) growth pattern of follicle center cells. This subtype behaves differently from typical follicular lymphoma and may have a more aggressive course. The unspecified site designation indicates incomplete documentation of anatomical location, which should prompt a query to obtain more specific information for both clinical and coding accuracy.
Documentation Requirements
- ✓Pathology report confirming diffuse follicle center lymphoma (not nodular/follicular pattern)
- ✓Attempt to identify specific anatomical site from imaging or clinical notes
- ✓Staging information (Ann Arbor or Lugano)
- ✓Treatment plan documenting whether active treatment or watchful waiting is appropriate
- ✓Immunohistochemistry results (CD10, BCL6, BCL2) supporting the diagnosis
Commonly Confused Codes
C82.40 — Follicular lymphoma grade IIIb, unspecified site: Follicular lymphoma has a follicular growth pattern; diffuse follicle center lymphoma has a diffuse pattern — pathology must specify the architectureC83.30 — Diffuse large B-cell lymphoma, unspecified site: Diffuse large B-cell lymphoma involves large transformed cells; diffuse follicle center lymphoma retains follicle center cell morphologyC82.90 — Follicular lymphoma, unspecified, unspecified site: Use C82.50 when the diffuse follicle center type is specified; use C82.90 when the follicular lymphoma type cannot be determined