C81.39
BillableLymphocyte depleted Hodgkin lymphoma, extranodal and solid organ sites
HCC Category Mapping
V28HCC 21 — Breast, Prostate, Colorectal and Other Cancers and Tumors
0.545V24HCC 10 — Lymphoma and Other Cancers
0.675ESRDHCC 10 — Lymphoma and Other Cancers
0.000RxHCCHCC 21 — Hodgkin Lymphoma and Other Cancers
0.000What This Code Means
A rare type of Hodgkin lymphoma (lymphocyte depleted variant) affecting organs or tissues outside the lymph node system.
Coding Tips
- •Use this code when the lymphoma involves solid organs or extranodal sites rather than lymph nodes
- •Document the specific organ or tissue involved in the medical record for clarity
Clinical Significance
Lymphocyte depleted Hodgkin lymphoma involving extranodal and solid organ sites represents the most advanced form of the most aggressive classical Hodgkin subtype. Organ involvement (liver, lungs, bone, bone marrow) indicates stage IV disease with a guarded prognosis. Treatment is intensive, often requiring modified chemotherapy protocols and close monitoring for treatment toxicities given the already compromised clinical status.
Documentation Requirements
- ✓Pathology confirming lymphocyte depleted Hodgkin lymphoma
- ✓Documentation of specific extranodal organ(s) involved with imaging or biopsy confirmation
- ✓Bone marrow biopsy results if marrow involvement is suspected
- ✓Stage IV Ann Arbor designation with identified extranodal sites
- ✓Provider assessment and active treatment documentation during the encounter
Commonly Confused Codes
C81.37 — Lymphocyte depleted Hodgkin lymphoma, spleen: use C81.37 specifically for splenic involvement; C81.39 is for other extranodal organsC81.38 — Lymphocyte depleted Hodgkin lymphoma, multiple lymph node sites: C81.38 covers nodal disease in multiple regions; C81.39 covers non-nodal organ involvementC78.00-C78.09 — Secondary malignant neoplasm of lung: do not use secondary neoplasm codes for lymphomatous lung involvement — code as primary lymphoma