C81.08
BillableNodular lymphocyte predominant Hodgkin lymphoma, lymph nodes of multiple sites
HCC Category Mapping
V28HCC 21 — Breast, Prostate, Colorectal and Other Cancers and Tumors
0.545V24HCC 10 — Lymphoma and Other Cancers
0.675ESRDHCC 10 — Lymphoma and Other Cancers
0.000RxHCCHCC 21 — Hodgkin Lymphoma and Other Cancers
0.000What This Code Means
Hodgkin lymphoma with nodular lymphocyte predominance affecting lymph nodes in multiple different areas of the body.
Coding Tips
- •Use this code only when disease involves lymph nodes in two or more distinct anatomical regions
- •Document all involved sites in the medical record for clinical reference
Clinical Significance
Nodular lymphocyte predominant Hodgkin lymphoma involving lymph nodes of multiple sites indicates disease in two or more distinct anatomic lymph node regions. Multi-site involvement typically represents more advanced disease (Stage II or higher) and generally requires systemic therapy rather than localized radiation alone. Despite multi-site involvement, NLPHL maintains a better prognosis compared to classic Hodgkin lymphoma subtypes.
Documentation Requirements
- ✓Pathology confirming NLPHL subtype
- ✓Documentation of at least two distinct lymph node regions involved
- ✓Imaging (PET/CT) showing all involved sites
- ✓Listing of all specific lymph node regions affected for clinical reference
- ✓Ann Arbor staging reflecting multi-site disease
- ✓Treatment plan appropriate for advanced-stage disease
Commonly Confused Codes
C81.01-C81.07 — Single site NLPHL codes: Use C81.08 only when disease involves two or more distinct anatomic regionsC81.18 — Nodular sclerosis Hodgkin lymphoma, multiple sites: Different subtype; verify pathologyC81.09 — NLPHL, extranodal and solid organ sites: Use C81.08 for multiple lymph node regions, not extranodal involvementC81.00 — NLPHL, unspecified site: Not interchangeable with C81.08; unspecified means unknown, not multiple