C81.05
BillableNodular lymphocyte predominant Hodgkin lymphoma, lymph nodes of inguinal region and lower limb
HCC Category Mapping
V28HCC 21 — Breast, Prostate, Colorectal and Other Cancers and Tumors
0.545V24HCC 10 — Lymphoma and Other Cancers
0.675ESRDHCC 10 — Lymphoma and Other Cancers
0.000RxHCCHCC 21 — Hodgkin Lymphoma and Other Cancers
0.000What This Code Means
A type of Hodgkin lymphoma affecting the lymph nodes in the groin and lower leg area, with nodular lymphocyte-predominant cell patterns.
Coding Tips
- •Ensure documentation specifies inguinal region and/or lower limb involvement to differentiate from other site codes
- •This code includes both inguinal lymph nodes and lower extremity nodes
Clinical Significance
Nodular lymphocyte predominant Hodgkin lymphoma involving inguinal and lower limb lymph nodes is a less common presentation but can be the initial site of disease in some patients. Inguinal lymphadenopathy in NLPHL tends to present as painless groin swelling and requires biopsy to differentiate from reactive lymphadenopathy or other lymphoma subtypes. This peripheral presentation often indicates limited-stage disease with favorable outcomes.
Documentation Requirements
- ✓Pathology confirming NLPHL subtype
- ✓Physical exam and imaging confirming inguinal region and/or lower limb lymph node involvement
- ✓Laterality documented (right, left, or bilateral)
- ✓Assessment for concurrent pelvic lymphadenopathy (which would be coded separately as C81.06)
- ✓Complete staging workup
- ✓Treatment plan
Commonly Confused Codes
C81.15 — Nodular sclerosis Hodgkin lymphoma, inguinal/lower limb: Different subtype; requires pathology confirmationC81.06 — NLPHL, intrapelvic lymph nodes: Inguinal nodes are superficial groin nodes; intrapelvic nodes are deep pelvic nodes — anatomically distinctC81.00 — NLPHL, unspecified site: Use C81.05 when inguinal involvement is documentedC84.44 — Peripheral T-cell lymphoma, inguinal: Completely different lymphoma type