C25.8 ICD-10-CM Code: Malignant neoplasm of overlapping sites of pancreas
C25.8 maps to CMS-HCC V28 20. A source-labeled RAF reference is available. Confirm the documented diagnosis and applicable coding requirements. MEAT criteria · RAF Calculator · free HCC coding tools
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FY 2026 Apr update / Neoplasms (C00-D49) / Malignant neoplasms of digestive organs (C15-C26)
C25.8
Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidanceMalignant neoplasm of overlapping sites of pancreas
Cancer that involves multiple overlapping areas of the pancreas rather than being confined to a single location.
Buddy Insight
Overlapping sites of pancreas indicates a malignancy that spans two or more anatomical regions of the pancreas, often indicating locally advanced disease.
CMS-HCC V28
MappedHCC 20
Coefficient HCC 20: 1.136 (Community Non-Dual Aged (CNA))
CMS-HCC V24
HistoricalHistorical
Not used for CY2026 payment
ACA/HHS
MappedHCC 009
Code-level coefficient reference
ESRD/PACE
MappedHCC 9
Code-level coefficient reference
RXHCC
MappedHCC 20
Code-level coefficient reference
Code Book Path
Inclusion Terms
OfficialNo inclusion terms are included in this display for C25.8. Check the code and parent instructions in the Code Book.
Excludes 2
Official- gastrointestinal stromal tumors (C49.A-)Inherited from C15-C26
Related Codes
Includes
OfficialNo Includes notes are included in this display for C25.8. Check the code and parent instructions in the Code Book.
Excludes 1
Official- Kaposi's sarcoma of gastrointestinal sites (C46.4)Inherited from C15-C26
Code First
OfficialNo Code First sequencing instructions are included in this display for C25.8. Check the code and parent instructions in the Code Book.
Use Additional
Official- code to identify:Inherited from C25
- alcohol abuse and dependence (F10.-)Inherited from C25
Code Also
Official- if applicable exocrine pancreatic insufficiency (K86.81)Inherited from C25
Buddy Documentation Tip
MEAT Support
Audit Caution
Common Mistakes
Current with CMS: FY2026 ICD-10-CM Apr 1 update (effective Apr 1 – Sep 30, 2026) · CMS-HCC V28, 100% phased in for payment year 2026. FY2027 code set already staged for October 1, 2026. How HCC Buddy stays current →
Is C25.8 an HCC code?
Yes. C25.8 (Malignant neoplasm of overlapping sites of pancreas) maps to HCC 20, Lung and Other Severe Cancers under the CMS-HCC V28 risk adjustment model, with a source-labeled community non-dual aged reference coefficient of 1.136. Source-labeled code-level coefficients are references, not member totals. Actual contribution depends on complete member context, hierarchy and cleanup rules, interactions, and model year. HCC Buddy's RAF Calculator supports CMS-HCC V28 PY2026 and shows no score unless every required source and calculation check passes. It is billable for payment year 2026.
Coder answer: C25.8 is billable and maps to V28 HCC 20, Lung and Other Severe Cancers. Open it in the Code Book for the tabular path, RAF, and MEAT checklist.
- Code
- C25.8
- Description
- Malignant neoplasm of overlapping sites of pancreas
- HCC (V28)
- HCC 20 — Lung and Other Severe Cancers
- RAF reference coefficient
- 1.136
- Billable
- Yes
- Payment year
- 2026
HCC Category Mapping
These are source-labeled model coefficients, not member totals. A category may still be removed by hierarchy or model cleanup rules. Weights are not directly comparable across models: CMS-HCC V28 and V24 use Community, Non-Dual, Aged; ESRD uses the dialysis continuing-enrollee model; RxHCC is the Part D continuing-enrollee, non-low-income, aged weight (a larger scale than CMS-HCC). ACA/HHS has no single weight — it varies by metal level. Actual per-patient RAF contribution depends on member context, hierarchy and cleanup rules, interactions, and the model year used by the payer. V28 is the CMS-HCC model phased in over payment years 2024–2026; V24 remains available for historical review.
Work C25.8 in the Code Book — tabular path, V28 RAF reference, and MEAT checklist →
MEAT review for C25.8
For C25.8, confirm that the documentation supports the diagnosis and meets the applicable coding, encounter, program and payer requirements. MEAT (Monitor, Evaluate, Assess, or Treat) is a review mnemonic, not a universal CMS coding rule.
- MMonitor: signs, symptoms, disease progression, or lab trending documented in the note
- EEvaluate: test results, medication response, or physical findings reviewed by the provider
- AAssess: explicit mention in the assessment or plan with acknowledgment of status
- TTreat: medication, referral, procedure, therapy, or counseling tied to the diagnosis
Coder workflow notes
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What This Code Means
C25.8 is the ICD-10-CM diagnosis code for malignant neoplasm of overlapping sites of pancreas. Cancer that involves multiple overlapping areas of the pancreas rather than being confined to a single location. C25.8 sits in the ICD-10-CM chapter for neoplasms (c00-d49), within the section covering malignant neoplasms of digestive organs (c15-c26).
Under the CMS-HCC V28 risk adjustment model, C25.8 maps to Lung and Other Severe Cancers (HCC 20) with a source-labeled community, non-dual, aged reference coefficient of 1.136. For CY2026 non-PACE Medicare Advantage, CMS uses 100% of the 2024 CMS-HCC model (V28). PACE uses a separate model blend. Source-labeled code-level coefficients are references, not member totals. Actual contribution depends on complete member context, hierarchy and cleanup rules, interactions, and model year. HCC Buddy's RAF Calculator supports CMS-HCC V28 PY2026 and shows no score unless every required source and calculation check passes.
Use this code when the tumor spans across two or more distinct regions of the pancreas. For C25.8, confirm that the documentation supports the diagnosis and meets the applicable coding, encounter, program and payer requirements. MEAT (Monitor, Evaluate, Assess, or Treat) is a review mnemonic, not a universal CMS coding rule. When documentation is ambiguous, coders should issue a provider query rather than assume the highest-specificity variant.
HCC Buddy maintains structured V28 and V24 mapping, source-labeled coefficient references, and MEAT documentation criteria for C25.8 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.
Coding Tips
- •Use this code when the tumor spans across two or more distinct regions of the pancreas
- •Document the specific sites involved (head, body, tail) in the medical record for clarity
Clinical Significance
Overlapping sites of pancreas indicates a malignancy that spans two or more anatomical regions of the pancreas, often indicating locally advanced disease. These tumors typically present at a later stage and may have a worse prognosis than tumors confined to a single site. Accurate coding reflects disease burden and supports appropriate resource allocation.
Documentation Requirements
- ✓Documentation of tumor involvement in two or more distinct pancreatic regions
- ✓Imaging or surgical reports showing the tumor crossing anatomical boundaries
- ✓Pathology confirmation of malignancy
- ✓Current stage and treatment status
- ✓Clear provider documentation that the tumor is not confined to a single pancreatic site
Commonly Confused Codes
- •C25.7: Other parts of pancreas: Use C25.7 for a single non-standard site; use C25.8 only when multiple regions are involved
- •C25.9: Unspecified pancreas: Do not use C25.9 as a default when overlapping sites are documented: C25.8 is more specific
- •C25.0-C25.4: Single-site pancreatic codes: If the primary site is identifiable despite extension, code the primary site