Yes. E76.8 is a billable ICD-10-CM code that can be reported on professional and institutional claims as a primary or secondary diagnosis when the provider documentation supports the specific condition described. Billable codes in ICD-10-CM are coded to the highest level of specificity available for the documented diagnosis. E76.8 is current for fiscal year 2026 and remains in the active CMS ICD-10-CM code set published by the National Center for Health Statistics.

What is the V28 vs V24 difference for E76.8?

CMS phased in the V28 risk adjustment model over payment years 2024 (33%), 2025 (67%), and 2026 (100%), replacing V24. V28 consolidates HCC categories, removes some lower-acuity conditions, and recalibrates RAF weights across the entire model. E76.8 was a payment HCC under V24 (Other Significant Endocrine and Metabolic Disorders) but the V28 recalibration removed it from the risk adjustment model. Both models can still appear in legacy data and in payer-specific lookback periods.

What should coders know when reporting E76.8?

This code is for glucosaminoglycan disorders that do not fit into the MPS classification categories Document the specific metabolic disorder name and any associated clinical features for clarity Because E76.8 maps to a payment HCC, the documentation must also satisfy MEAT criteria (Monitor, Evaluate, Assess, or Treat) for the encounter to count toward the patient's risk adjustment score.

E76.8: Other disorders of glucosaminoglycan metabolism — ICD-10 | Other Significant Endocrine

ICD-10-CM Code View

HCC Buddy Code Card

Digital ICD-10 code-book layout with official code detail, always-visible risk models, Code Trumping, and Buddy coding guidance.

Code lookupE76.8Effective periodFY2026 Apr Update (Apr 1-Sep 30)

FY 2026 Apr update / Endocrine, nutritional and metabolic diseases (E00-E89) / Metabolic disorders (E70-E88)

E76.8

Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidance

Other disorders of glucosaminoglycan metabolism

Other disorders of glucosaminoglycan metabolism include rare inherited metabolic conditions affecting how the body processes complex sugars, excluding the standard mucopolysaccharidosis types.

Buddy Insight

Other disorders of glucosaminoglycan metabolism captures conditions involving abnormal glycosaminoglycan (GAG) processing that do not meet criteria for classified mucopolysaccharidoses.

CMS-HCC V28

Not risk-adjusted for this model/period.

RAF 0

CMS-HCC V24

Mapped

HCC 23

Other Significant Endocrine a...

RAF 0.230

ACA/HHS

Not risk-adjusted for this model/period.

RAF 0

ESRD/PACE

Mapped

HCC 23

Other Significant Endocrine a...

RAF 0.0

RXHCC

Mapped

HCC 43

Other Significant Endocrine a...

RAF 0.0

Code Trumping

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Code Book Path

Official

E76Disorders of glycosaminoglycan metabolism

E76.8Other disorders of glucosaminoglycan metabolism

Inclusion Terms

Official

ICD-10-CM does not list inclusion terms for E76.8 in this effective period.

Excludes 2

Official

ICD-10-CM does not list Excludes 2 notes for E76.8 in this effective period.

Related Child Codes

Official

E76.0Mucopolysaccharidosis, type I

E76.1Mucopolysaccharidosis, type II

E76.2Other mucopolysaccharidoses

E76.3Mucopolysaccharidosis, unspecified

E76.9Glucosaminoglycan metabolism disorder, unspecified

Includes

Official

ICD-10-CM does not list Includes notes for E76.8 in this effective period.

Excludes 1

Official

ICD-10-CM does not list Excludes 1 notes for E76.8 in this effective period.

Code First

Official

ICD-10-CM does not list Code First sequencing instructions for E76.8 in this effective period.

Use Additional

Official

ICD-10-CM does not list Use Additional Code instructions for E76.8 in this effective period.

Code Also

Official

ICD-10-CM does not list Code Also instructions for E76.8 in this effective period.

Buddy Documentation Tip

HCC Buddy guidance

Specific GAG metabolism disorder documented (if named condition exists)

Confirmatory diagnostic testing differentiating this from classified MPS types

Clinical manifestations related to abnormal GAG metabolism

Provider statement confirming this is a GAG metabolism disorder NOT classified as a specific MPS type

MEAT Support

HCC Buddy guidance

Specific GAG metabolism disorder documented (if named condition exists)

Confirmatory diagnostic testing differentiating this from classified MPS types

Clinical manifestations related to abnormal GAG metabolism

Provider statement confirming this is a GAG metabolism disorder NOT classified as a specific MPS type

Audit Caution

HCC Buddy guidance

Using E76.8 for conditions that should be coded to specific MPS types

Confusing glucosaminoglycan disorders with glycoprotein metabolism disorders (E77 category)

Not recognizing that this code is for GAG metabolism disorders OUTSIDE the MPS classification

Using this code without sufficient diagnostic evidence differentiating it from a classified MPS

Common Mistakes

HCC Buddy guidance

E76.01-E76.29 — Specific MPS types: each classified MPS has its own code and should not use E76.8

E76.3 — Mucopolysaccharidosis, unspecified: for conditions confirmed as MPS but type unknown

E76.9 — Glucosaminoglycan metabolism disorder, unspecified: use only when the specific disorder cannot be identified

E77.8 — Other disorders of glycoprotein metabolism: different metabolic pathway (glycoproteins vs. GAGs)

Last updated: FY2026 ICD-10-CM Apr update, Apr 1, 2026 through Sep 30, 2026. CMS-HCC V28 is 100% phased in for payment year 2026.

Is E76.8 an HCC code?

Yes. E76.8 maps to Other Significant Endocrine and Metabolic Disorders under the V24 model but is not retained in V28.

HCC Category Mapping

V24HCC 23, Other Significant Endocrine and Metabolic Disorders

0.230

ESRDHCC 23, Other Significant Endocrine and Metabolic Disorders

0.000

RxHCCHCC 43, Other Significant Endocrine and Metabolic Disorders

0.000

RAF weights shown are the community, non-dual, aged base weights from the CMS risk adjustment model file. Actual per-patient RAF contribution depends on member segment, interactions, and the model year used by the payer. V28 is the CMS-HCC model phased in over payment years 2024–2026; V24 remains in use during the transition and for historical data.

Work E76.8 in the Code Book — tabular path, V28 RAF, and MEAT checklist →

MEAT Criteria for E76.8

For E76.8to count as a valid HCC diagnosis in a given encounter, the provider's documentation must show MEAT: Monitor, Evaluate, Assess, or Treat. A diagnosis from a prior year does not carry forward automatically, it has to be re-documented and supported each calendar year.

MMonitor: signs, symptoms, disease progression, or lab trending documented in the note
EEvaluate: test results, medication response, or physical findings reviewed by the provider
AAssess: explicit mention in the assessment or plan with acknowledgment of status
TTreat: medication, referral, procedure, therapy, or counseling tied to the diagnosis

Only one of M/E/A/T is required to support the code, but the documentation must be specific enough to show that the provider actually addressed E76.8 during that encounter, not just copy-forwarded from a problem list.

Coder workflow notes

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What This Code Means

E76.8 is the ICD-10-CM diagnosis code for other disorders of glucosaminoglycan metabolism. Other disorders of glucosaminoglycan metabolism include rare inherited metabolic conditions affecting how the body processes complex sugars, excluding the standard mucopolysaccharidosis types. E76.8 sits in the ICD-10-CM chapter for endocrine, nutritional and metabolic diseases (e00-e89), within the section covering metabolic disorders (e70-e88).

Under the older CMS-HCC V24 model, E76.8 maps to Other Significant Endocrine and Metabolic Disorders (HCC 23) with a community, non-dual, aged base RAF weight of 0.230. V28 is the CMS-HCC risk adjustment model that reached 100% phase-in for payment year 2026, replacing V24 which was used during the PY2024–PY2025 transition.

This code is for glucosaminoglycan disorders that do not fit into the MPS classification categories. Because E76.8 maps to a payment HCC, the provider's documentation must satisfy MEAT criteria (Monitor, Evaluate, Assess, or Treat) for the encounter to count toward the patient's Medicare Advantage risk adjustment score. When documentation is ambiguous, coders should issue a provider query rather than assume the highest-specificity variant.

HCC Buddy maintains structured V28 and V24 mapping, RAF weights, and MEAT documentation criteria for E76.8 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.

Coding Tips

•This code is for glucosaminoglycan disorders that do not fit into the MPS classification categories
•Document the specific metabolic disorder name and any associated clinical features for clarity

Clinical Significance

Other disorders of glucosaminoglycan metabolism captures conditions involving abnormal glycosaminoglycan (GAG) processing that do not meet criteria for classified mucopolysaccharidoses. These include rare conditions such as hyaluronidase deficiency and other non-MPS GAG metabolism disorders that still require metabolic specialist management.

Documentation Requirements

✓Specific GAG metabolism disorder documented (if named condition exists)
✓Confirmatory diagnostic testing differentiating this from classified MPS types
✓Clinical manifestations related to abnormal GAG metabolism
✓Provider statement confirming this is a GAG metabolism disorder NOT classified as a specific MPS type
✓Treatment plan and follow-up schedule

Commonly Confused Codes

•E76.01-E76.29: Specific MPS types: each classified MPS has its own code and should not use E76.8
•E76.3: Mucopolysaccharidosis, unspecified: for conditions confirmed as MPS but type unknown
•E76.9: Glucosaminoglycan metabolism disorder, unspecified: use only when the specific disorder cannot be identified
•E77.8: Other disorders of glycoprotein metabolism: different metabolic pathway (glycoproteins vs. GAGs)