E72.89 ICD-10-CM Code: Other specified disorders of amino-acid metabolism
HCC Buddy Code Card
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FY 2026 Apr update / Endocrine, nutritional and metabolic diseases (E00-E89) / Metabolic disorders (E70-E88)
E72.89
Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidanceOther specified disorders of amino-acid metabolism
A rare metabolic disorder affecting how the body processes amino acids (building blocks of proteins), with specific characteristics not covered by other amino acid metabolism codes.
Buddy Insight
Other specified disorders of amino-acid metabolism captures a wide range of rare inborn errors of amino acid processing that do not have individual ICD-10 codes.
CMS-HCC V28
00
RAF 0
CMS-HCC V24
MappedHCC 23
RAF 0.230
ACA/HHS
00
RAF 0
ESRD/PACE
MappedHCC 23
RAF 0.0
RXHCC
MappedHCC 43
RAF 0.0
Code Trumping
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Code Book Path
Inclusion Terms
Official- Disorders of beta-amino-acid metabolism
- Disorders of gamma-glutamyl cycle
Excludes 2
OfficialICD-10-CM does not list Excludes 2 notes for E72.89 in this effective period.
Related Child Codes
Includes
OfficialICD-10-CM does not list Includes notes for E72.89 in this effective period.
Excludes 1
OfficialICD-10-CM does not list Excludes 1 notes for E72.89 in this effective period.
Code First
OfficialICD-10-CM does not list Code First sequencing instructions for E72.89 in this effective period.
Use Additional
OfficialICD-10-CM does not list Use Additional Code instructions for E72.89 in this effective period.
Code Also
OfficialICD-10-CM does not list Code Also instructions for E72.89 in this effective period.
Buddy Documentation Tip
MEAT Support
Audit Caution
Common Mistakes
Last updated: FY2026 ICD-10-CM Apr update, Apr 1, 2026 through Sep 30, 2026. CMS-HCC V28 is 100% phased in for payment year 2026.
Is E72.89 an HCC code?
Yes. E72.89 maps to Other Significant Endocrine and Metabolic Disorders under the V24 model but is not retained in V28.
HCC Category Mapping
RAF weights shown are the community, non-dual, aged base weights from the CMS risk adjustment model file. Actual per-patient RAF contribution depends on member segment, interactions, and the model year used by the payer. V28 is the CMS-HCC model phased in over payment years 2024–2026; V24 remains in use during the transition and for historical data.
MEAT Criteria for E72.89
For E72.89to count as a valid HCC diagnosis in a given encounter, the provider's documentation must show MEAT: Monitor, Evaluate, Assess, or Treat. A diagnosis from a prior year does not carry forward automatically, it has to be re-documented and supported each calendar year.
- MMonitor: signs, symptoms, disease progression, or lab trending documented in the note
- EEvaluate: test results, medication response, or physical findings reviewed by the provider
- AAssess: explicit mention in the assessment or plan with acknowledgment of status
- TTreat: medication, referral, procedure, therapy, or counseling tied to the diagnosis
Only one of M/E/A/T is required to support the code, but the documentation must be specific enough to show that the provider actually addressed E72.89 during that encounter, not just copy-forwarded from a problem list.
What This Code Means
E72.89 is the ICD-10-CM diagnosis code for other specified disorders of amino-acid metabolism. A rare metabolic disorder affecting how the body processes amino acids (building blocks of proteins), with specific characteristics not covered by other amino acid metabolism codes. E72.89 sits in the ICD-10-CM chapter for endocrine, nutritional and metabolic diseases (e00-e89), within the section covering metabolic disorders (e70-e88).
Under the older CMS-HCC V24 model, E72.89 maps to Other Significant Endocrine and Metabolic Disorders (HCC 23) with a community, non-dual, aged base RAF weight of 0.230. V28 is the CMS-HCC risk adjustment model that reached 100% phase-in for payment year 2026, replacing V24 which was used during the PY2024–PY2025 transition.
Use this code only after ruling out more specific amino acid disorders; documentation should clearly describe the metabolic abnormality. Because E72.89 maps to a payment HCC, the provider's documentation must satisfy MEAT criteria (Monitor, Evaluate, Assess, or Treat) for the encounter to count toward the patient's Medicare Advantage risk adjustment score. When documentation is ambiguous, coders should issue a provider query rather than assume the highest-specificity variant.
HCC Buddy maintains structured V28 and V24 mapping, RAF weights, and MEAT documentation criteria for E72.89 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.
Coding Tips
- •Use this code only after ruling out more specific amino acid disorders; documentation should clearly describe the metabolic abnormality
- •Verify the specific amino acid involved and whether a more specific code exists before assigning this 'other specified' category
Clinical Significance
Other specified disorders of amino-acid metabolism captures a wide range of rare inborn errors of amino acid processing that do not have individual ICD-10 codes. These can include disorders of proline, histidine, tryptophan, or other amino acid pathways. Many carry significant morbidity including intellectual disability, organ damage, and metabolic crises. Accurate coding is essential to reflect the complex, lifelong care these patients need.
Documentation Requirements
- ✓Specific amino acid metabolism disorder named by the provider
- ✓Biochemical confirmation via plasma amino acid panel, urine organic acids, or specialized metabolic testing
- ✓Genetic testing results identifying the specific enzyme deficiency if available
- ✓Current treatment including dietary modifications, supplements, or medications
- ✓Documentation of associated complications or organ involvement
Commonly Confused Codes
- •E72.9 — Disorder of amino-acid metabolism, unspecified: only use when no specific disorder is identified
- •E72.81 — Disorders of gamma aminobutyric acid metabolism: has its own specific code
- •E70.0-E70.9 — Disorders of aromatic amino-acid metabolism: phenylalanine and tyrosine disorders have separate codes
- •E71.0-E71.5 — Disorders of branched-chain amino-acid metabolism: maple syrup urine disease and others have specific codes