What is ICD-10 code E72.89?

E72.89 is the ICD-10-CM diagnosis code for Other specified disorders of amino-acid metabolism. A rare metabolic disorder affecting how the body processes amino acids (building blocks of proteins), with specific characteristics not covered by other amino acid metabolism codes. E72.89 is a billable code, meaning it can be reported on a claim as a primary or secondary diagnosis when supported by documentation. E72.89 is part of the FY2026 ICD-10-CM code set published by the CMS National Center for Health Statistics and used on Medicare, Medicaid, and commercial claims in the United States.

Yes. E72.89 is a billable ICD-10-CM code that can be reported on professional and institutional claims as a primary or secondary diagnosis when the provider documentation supports the specific condition described. Billable codes in ICD-10-CM are coded to the highest level of specificity available for the documented diagnosis. E72.89 is current for fiscal year 2026 and remains in the active CMS ICD-10-CM code set published by the National Center for Health Statistics.

Which HCC does E72.89 map to under V28?

E72.89 has no payable CMS-HCC V28 mapping in the final FY2026 CMS file.

What RAF reference is published for E72.89?

E72.89 has no V28 reference coefficient because the final FY2026 source verifies no payable V28 mapping.

What is the V28 vs V24 difference for E72.89?

E72.89 has verified no payable V28 mapping in the final FY2026 source. Select a historical effective period before making any V24 comparison.

What documentation supports E72.89?

Use this code only after ruling out more specific amino acid disorders; documentation should clearly describe the metabolic abnormality Verify the specific amino acid involved and whether a more specific code exists before assigning this 'other specified' category E72.89 is not a CMS-HCC V28 payment code in the verified current source, so MEAT is not the payment hook. Documentation still has to support the diagnosis if you report it.

2026 ICD-10-CM E72.89: Other specified disorders

E72.89 is not a CMS-HCC payment code. MEAT criteria · RAF Calculator · HCC Buddy coding tools

ICD-10-CM Code View

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Code lookupE72.89

Effective periodFY2026 Apr Update (Apr 1-Sep 30)

FY 2026 Apr update / Endocrine, nutritional and metabolic diseases (E00-E89) / Metabolic disorders (E70-E88)

E72.89

Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidance

Other specified disorders of amino-acid metabolism

A rare metabolic disorder affecting how the body processes amino acids (building blocks of proteins), with specific characteristics not covered by other amino acid metabolism codes.

Buddy Insight

Other specified disorders of amino-acid metabolism captures a wide range of rare inborn errors of amino acid processing that do not have individual ICD-10 codes.

Overview Risk Models Code Book Documentation Audit Notes Edition comparison

CMS-HCC V28

N/A

—

Not risk-adjusted for this model/period.

Not mapped

CMS-HCC V24

Historical

Not used for standard CY2026 Medicare Advantage payment. Select a historical period to review V24.

Not used for CY2026 payment

ACA/HHS

N/A

—

Not risk-adjusted for this model/period.

Not mapped

ESRD/PACE

N/A

—

Not risk-adjusted for this model/period.

Not mapped

RXHCC

Mapped

HCC 43

Pituitary, Adrenal Gland, and...

Code-level coefficient reference

Code Book Path

Official

E72Other disorders of amino-acid metabolism E72.8Other specified disorders of amino-acid metabolism E72.89Other specified disorders of amino-acid metabolism

Inclusion Terms

Official

Disorders of beta-amino-acid metabolism
Disorders of gamma-glutamyl cycle

Excludes 2

Official

Ehlers-Danlos syndromes (Q79.6-)Inherited from E70-E88

Related Codes

Official

E72.81Disorders of gamma aminobutyric acid metabolism

Includes

Official

No Includes notes are included in this display for E72.89. Check the code and parent instructions in the Code Book.

Excludes 1

Official

transitory endocrine and metabolic disorders specific to newborn (P70-P74)Inherited from E00-E89, E70-E88, E72
androgen insensitivity syndrome (E34.5-)Inherited from E00-E89, E70-E88, E72
congenital adrenal hyperplasia (E25.0)Inherited from E00-E89, E70-E88, E72
hemolytic anemias attributable to enzyme disorders (D55.-)Inherited from E00-E89, E70-E88, E72
Marfan syndrome (Q87.4-)Inherited from E00-E89, E70-E88, E72
5-alpha-reductase deficiency (E29.1)Inherited from E00-E89, E70-E88, E72
disorders of:Inherited from E00-E89, E70-E88, E72
aromatic amino-acid metabolism (E70.-)Inherited from E00-E89, E70-E88, E72
branched-chain amino-acid metabolism (E71.0-E71.2)Inherited from E00-E89, E70-E88, E72
fatty-acid metabolism (E71.3)Inherited from E00-E89, E70-E88, E72
purine and pyrimidine metabolism (E79.-)Inherited from E00-E89, E70-E88, E72
gout (M1A.-, M10.-)Inherited from E00-E89, E70-E88, E72

Code First

Official

No Code First sequencing instructions are included in this display for E72.89. Check the code and parent instructions in the Code Book.

Use Additional

Official

No Use Additional Code instructions are included in this display for E72.89. Check the code and parent instructions in the Code Book.

Code Also

Official

No Code Also instructions are included in this display for E72.89. Check the code and parent instructions in the Code Book.

Buddy Documentation Tip

HCC Buddy guidance

Specific amino acid metabolism disorder named by the provider

Biochemical confirmation via plasma amino acid panel, urine organic acids, or specialized metabolic testing

Genetic testing results identifying the specific enzyme deficiency if available

Current treatment including dietary modifications, supplements, or medications

MEAT Support

HCC Buddy guidance

Specific amino acid metabolism disorder named by the provider

Biochemical confirmation via plasma amino acid panel, urine organic acids, or specialized metabolic testing

Genetic testing results identifying the specific enzyme deficiency if available

Current treatment including dietary modifications, supplements, or medications

Audit Caution

HCC Buddy guidance

Using this residual code when a more specific amino acid metabolism code exists elsewhere in E70-E72

Defaulting to E72.9 (unspecified) when the specific amino acid disorder is documented but just lacks its own unique code

Confusing amino acid metabolism disorders with organic acid disorders or fatty acid oxidation defects

Not coding the specific clinical manifestations (seizures, intellectual disability, organ damage) as secondary diagnoses

Common Mistakes

HCC Buddy guidance

E72.9 — Disorder of amino-acid metabolism, unspecified: only use when no specific disorder is identified

E72.81 — Disorders of gamma aminobutyric acid metabolism: has its own specific code

E70.0-E70.9 — Disorders of aromatic amino-acid metabolism: phenylalanine and tyrosine disorders have separate codes

E71.0-E71.5 — Disorders of branched-chain amino-acid metabolism: maple syrup urine disease and others have specific codes

Current with CMS: FY2026 ICD-10-CM Apr 1 update (effective Apr 1 – Sep 30, 2026) · CMS-HCC V28, 100% phased in for payment year 2026. FY2027 code set already staged for October 1, 2026. How HCC Buddy stays current →

Is E72.89 an HCC code?

E72.89 is not in the CMS-HCC V28 or V24 community payment model. E72.89 has a separate mapping under the CMS-HCC ESRD model (HCC 23 (Other Significant Endocrine and Metabolic Disorders)) and the Part D RxHCC model (HCC 43 (Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders)); the applicable result needs member context. E72.89 also appears in the HHS-HCC commercial risk model (HCC 028 (HHS-HCC 028 child, RAF varies by metal level)), where the result depends on member context and is not a Medicare Advantage payment mapping.

Code: E72.89
Description: Other specified disorders of amino-acid metabolism
HCC (V28): No CMS-HCC V28 mapping
RAF reference coefficient: —
Billable: Yes
Payment year: 2026

HCC Category Mapping

RxHCCHCC 43, Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders

Not separately weighted

These are source-labeled model coefficients, not member totals. A category may still be removed by hierarchy or model cleanup rules. Weights are not directly comparable across models: CMS-HCC V28 and V24 use Community, Non-Dual, Aged; ESRD uses the dialysis continuing-enrollee model; RxHCC is the Part D continuing-enrollee, non-low-income, aged weight (a larger scale than CMS-HCC). ACA/HHS has no single weight — it varies by metal level. Actual per-patient RAF contribution depends on member context, hierarchy and cleanup rules, interactions, and the model year used by the payer. V28 is the CMS-HCC model phased in over payment years 2024–2026; V24 remains available for historical review.

Work E72.89 in the Code Book — tabular path, V28 RAF reference, and MEAT checklist →

MEAT review for E72.89

For E72.89, confirm that the documentation supports the diagnosis and meets the applicable coding, encounter, program and payer requirements. MEAT (Monitor, Evaluate, Assess, or Treat) is a review mnemonic, not a universal CMS coding rule.

MMonitor: signs, symptoms, disease progression, or lab trending documented in the note
EEvaluate: test results, medication response, or physical findings reviewed by the provider
AAssess: explicit mention in the assessment or plan with acknowledgment of status
TTreat: medication, referral, procedure, therapy, or counseling tied to the diagnosis

Coder workflow notes

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What This Code Means

E72.89 is the ICD-10-CM diagnosis code for other specified disorders of amino-acid metabolism. A rare metabolic disorder affecting how the body processes amino acids (building blocks of proteins), with specific characteristics not covered by other amino acid metabolism codes. E72.89 sits in the ICD-10-CM chapter for endocrine, nutritional and metabolic diseases (e00-e89), within the section covering metabolic disorders (e70-e88).

E72.89 has no mapping under the CMS-HCC V28 or V24 community payment models. E72.89 has a separate mapping under the CMS-HCC ESRD model (HCC 23 (Other Significant Endocrine and Metabolic Disorders)) and the Part D RxHCC model (HCC 43 (Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders)); the applicable result needs member context. E72.89 also appears in the HHS-HCC commercial risk model (HCC 028 (HHS-HCC 028 child, RAF varies by metal level)), where the result depends on member context and is not a Medicare Advantage payment mapping. Do not assign V28 risk adjustment value from this page; verify the applicable model and payment year before using this code for risk adjustment.

Use this code only after ruling out more specific amino acid disorders; documentation should clearly describe the metabolic abnormality.

HCC Buddy maintains structured V28 and V24 mapping, source-labeled coefficient references, and MEAT documentation criteria for E72.89 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.

Coding Tips

•Use this code only after ruling out more specific amino acid disorders; documentation should clearly describe the metabolic abnormality
•Verify the specific amino acid involved and whether a more specific code exists before assigning this 'other specified' category

Clinical Significance

Other specified disorders of amino-acid metabolism captures a wide range of rare inborn errors of amino acid processing that do not have individual ICD-10 codes. These can include disorders of proline, histidine, tryptophan, or other amino acid pathways. Many carry significant morbidity including intellectual disability, organ damage, and metabolic crises. Accurate coding is essential to reflect the complex, lifelong care these patients need.

Documentation Requirements

✓Specific amino acid metabolism disorder named by the provider
✓Biochemical confirmation via plasma amino acid panel, urine organic acids, or specialized metabolic testing
✓Genetic testing results identifying the specific enzyme deficiency if available
✓Current treatment including dietary modifications, supplements, or medications
✓Documentation of associated complications or organ involvement

Commonly Confused Codes

•E72.9: Disorder of amino-acid metabolism, unspecified: only use when no specific disorder is identified
•E72.81: Disorders of gamma aminobutyric acid metabolism: has its own specific code
•E70.0-E70.9: Disorders of aromatic amino-acid metabolism: phenylalanine and tyrosine disorders have separate codes
•E71.0-E71.5: Disorders of branched-chain amino-acid metabolism: maple syrup urine disease and others have specific codes

Child Codes

E72.81Disorders of gamma aminobutyric acid metabolism

E72.89Other specified disorders of amino-acid metabolism

Code Hierarchy

└E72Other disorders of amino-acid metabolism └E72.8Other specified disorders of amino-acid metabolism └E72.89Other specified disorders of amino-acid metabolism

└E72.89Other specified disorders of amino-acid metabolism

HCC Buddy Code Card

E72.89

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HCC Category Mapping

MEAT review for E72.89

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What This Code Means

Coding Tips

Clinical Significance

Documentation Requirements

Commonly Confused Codes

Child Codes

Code Hierarchy

E72.89 code history

Work E72.89 in HCC Buddy

E72.89 ICD-10-CM Code: Other specified disorders of amino-acid metabolism

HCC Buddy Code Card

E72.89

Is E72.89 an HCC code?

HCC Category Mapping

MEAT review for E72.89

Get the V28 mapping + MEAT cheat sheet

What This Code Means

Coding Tips

Clinical Significance

Documentation Requirements

Commonly Confused Codes

Child Codes

Code Hierarchy

E72.89 code history

Work E72.89 in HCC Buddy