D89.832 ICD-10-CM Code: Cytokine release syndrome, grade 2

D89.832 is the ICD-10-CM diagnosis code for cytokine release syndrome, grade 2. Cytokine release syndrome grade 2 is a moderate immune system reaction where the body releases excessive inflammatory chemicals (cytokines), typically occurring as a side effect of certain cancer treatments or immunotherapies. This grade involves moderate symptoms that may require medical intervention but are not immediately life-threatening. D89.832 sits in the ICD-10-CM chapter for diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (d50-d89), within the section covering certain disorders involving the immune mechanism (d80-d89).

D89.832 is a billable ICD-10-CM code but does not map to a payment HCC under the CMS-HCC V28, V24, ESRD, or RxHCC risk adjustment models. It can be reported on Medicare Advantage encounter data submissions but it does not contribute to a beneficiary's RAF score and therefore does not affect risk-adjusted payments to the plan.

This code is commonly associated with CAR-T cell therapy, checkpoint inhibitors, and monoclonal antibody treatments—always verify the triggering medication or treatment in the clinical documentation.