What is ICD-10 code D82.2?

D82.2 is the ICD-10-CM diagnosis code for Immunodeficiency with short-limbed stature. A rare genetic condition where the immune system is weakened and the person has unusually short limbs and stature. D82.2 is a billable code, meaning it can be reported on a claim as a primary or secondary diagnosis when supported by documentation. D82.2 is part of the FY2026 ICD-10-CM code set published by the CMS National Center for Health Statistics and used on Medicare, Medicaid, and commercial claims in the United States.

Yes. D82.2 is a billable ICD-10-CM code that can be reported on professional and institutional claims as a primary or secondary diagnosis when the provider documentation supports the specific condition described. Billable codes in ICD-10-CM are coded to the highest level of specificity available for the documented diagnosis. D82.2 is current for fiscal year 2026 and remains in the active CMS ICD-10-CM code set published by the National Center for Health Statistics.

Which HCC does D82.2 map to under V28?

D82.2 has no payable CMS-HCC V28 mapping in the final FY2026 CMS file.

What RAF reference is published for D82.2?

D82.2 has no V28 reference coefficient because the final FY2026 source verifies no payable V28 mapping.

What is the V28 vs V24 difference for D82.2?

D82.2 has verified no payable V28 mapping in the final FY2026 source. Select a historical effective period before making any V24 comparison.

What documentation supports D82.2?

This code represents a specific syndrome; document the short stature findings and immunodeficiency manifestations separately if needed Verify the diagnosis includes both immunodeficiency AND short-limbed stature to distinguish from other immunodeficiency disorders D82.2 is not a CMS-HCC V28 payment code in the verified current source, so MEAT is not the payment hook. Documentation still has to support the diagnosis if you report it.

Can D82.2 be a primary diagnosis?

Yes. D82.2 carries no code-first instruction in the FY2026 tabular, so it can be the first-listed diagnosis when it is the condition chiefly responsible for the encounter and the note supports it, and it can also be reported as a secondary diagnosis. For risk adjustment the order does not matter; the V28 category is the same either way.

Which codes cannot be reported with D82.2?

The Excludes1 note that applies to D82.2 lists autoimmune disease (systemic) NOS (M35.9); functional disorders of polymorphonuclear neutrophils (D71-); human immunodeficiency virus [HIV] disease (B20); ataxia telangiectasia [Louis-Bar] (G11.3). An Excludes1 condition is not reported together with D82.2; report one or the other, unless the two conditions are unrelated, which the ICD-10-CM Official Guidelines (Section I.A.12.a) allow. The Excludes2 note lists autoimmune disease (systemic) NOS (M35.9); certain conditions originating in the perinatal period (P00-P96); complications of pregnancy, childbirth and the puerperium (O00-O9A); congenital malformations, deformations and chromosomal abnormalities (Q00-Q99); and 5 more (see the notes on this page); those are separate conditions that may be reported together with D82.2 when both are documented.

2026 ICD-10-CM D82.2: Immunodeficiency with short-limbed

D82.2 is not a CMS-HCC payment code. MEAT criteria · RAF Calculator · HCC Buddy coding tools

ICD-10-CM Code View

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Code lookupD82.2

Effective periodFY2026 Apr Update (Apr 1-Sep 30)

FY 2026 Apr update / Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89) / Certain disorders involving the immune mechanism (D80-D89)

D82.2

Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidance

Immunodeficiency with short-limbed stature

A rare genetic condition where the immune system is weakened and the person has unusually short limbs and stature.

Buddy Insight

Immunodeficiency with short-limbed stature, also known as cartilage-hair hypoplasia or short-limbed immune deficiency, is a rare autosomal recessive disorder caused by RMRP gene mutations.

Overview Risk Models Code Book Documentation Audit Notes Edition comparison

CMS-HCC V28

N/A

—

Not risk-adjusted for this model/period.

Not mapped

CMS-HCC V24

Historical

Not used for standard CY2026 Medicare Advantage payment. Select a historical period to review V24.

Not used for CY2026 payment

ACA/HHS

Mapped

HCC 074

HHS-HCC 074 adult, RAF varies...

Code-level coefficient reference

ESRD/PACE

Mapped

HCC 47

Disorders of Immunity

Code-level coefficient reference

RXHCC

Mapped

HCC 99

Immune Disorders

Code-level coefficient reference

Code Book Path

Official

D82Immunodeficiency associated with other major defects D82.2Immunodeficiency with short-limbed stature

Inclusion Terms

Official

No inclusion terms are included in this display for D82.2. Check the code and parent instructions in the Code Book.

Excludes 2

Official

autoimmune disease (systemic) NOS (M35.9)Inherited from D50-D89
certain conditions originating in the perinatal period (P00-P96)Inherited from D50-D89
complications of pregnancy, childbirth and the puerperium (O00-O9A)Inherited from D50-D89
congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)Inherited from D50-D89
endocrine, nutritional and metabolic diseases (E00-E88)Inherited from D50-D89
human immunodeficiency virus [HIV] disease (B20)Inherited from D50-D89
injury, poisoning and certain other consequences of external causes (S00-T88)Inherited from D50-D89
neoplasms (C00-D49)Inherited from D50-D89
symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)Inherited from D50-D89

Related Codes

Official

D82.0Wiskott-Aldrich syndrome D82.1Di George's syndrome D82.3Immunodeficiency following hereditary defective response to Epstein-Barr virus D82.4Hyperimmunoglobulin E [IgE] syndrome D82.8Immunodeficiency associated with other specified major defects

Includes

Official

defects in the complement systemInherited from D80-D89
immunodeficiency disorders, except human immunodeficiency virus [HIV] diseaseInherited from D80-D89
sarcoidosisInherited from D80-D89

Excludes 1

Official

autoimmune disease (systemic) NOS (M35.9)Inherited from D80-D89, D82
functional disorders of polymorphonuclear neutrophils (D71-)Inherited from D80-D89, D82
human immunodeficiency virus [HIV] disease (B20)Inherited from D80-D89, D82
ataxia telangiectasia [Louis-Bar] (G11.3)Inherited from D80-D89, D82

Code First

Official

No Code First sequencing instructions are included in this display for D82.2. Check the code and parent instructions in the Code Book.

Use Additional

Official

No Use Additional Code instructions are included in this display for D82.2. Check the code and parent instructions in the Code Book.

Code Also

Official

No Code Also instructions are included in this display for D82.2. Check the code and parent instructions in the Code Book.

Buddy Documentation Tip

HCC Buddy guidance

Documentation must include genetic testing confirming RMRP mutation, skeletal survey showing metaphyseal dysplasia and short limbs, immunological assessment (lymphocyte subsets, immunoglobulin levels, vaccine responses), growth parameters, and cancer surveillance plan.

Document the specific severity of immune impairment and any associated features such as Hirschsprung disease or anemia.

MEAT Support

HCC Buddy guidance

Document the specific severity of immune impairment and any associated features such as Hirschsprung disease or anemia.

Audit Caution

HCC Buddy guidance

The short-limbed stature must be documented as part of the syndromic immunodeficiency, not as a coincidental finding.

If immunodeficiency is absent or trivial with only skeletal features, a skeletal dysplasia code may be more appropriate.

Code associated conditions (anemia, Hirschsprung disease, malignancies) separately when present.

Common Mistakes

HCC Buddy guidance

D82.1 (DiGeorge syndrome, a different syndromic immunodeficiency), D82.0 (Wiskott-Aldrich syndrome with different associated features), D81.89 (other combined immunodeficiencies without skeletal features), Q77.0 (achondrogenesis for skeletal dysplasia without immunodeficiency).

Current with CMS: FY2026 ICD-10-CM Apr 1 update (effective Apr 1 – Sep 30, 2026) · CMS-HCC V28, 100% phased in for payment year 2026. FY2027 code set already staged for October 1, 2026. How HCC Buddy stays current →

Is D82.2 an HCC code?

D82.2 is not in the CMS-HCC V28 or V24 community payment model. D82.2 has a separate mapping under the CMS-HCC ESRD model (HCC 47 (Disorders of Immunity)) and the Part D RxHCC model (HCC 99 (Immune Disorders)); the applicable result needs member context. D82.2 also appears in the HHS-HCC commercial risk model (HCC 074 (HHS-HCC 074 adult, RAF varies by metal level)), which is a commercial market model rather than a Medicare Advantage payment mapping.

Code: D82.2
Description: Immunodeficiency with short-limbed stature
HCC (V28): No CMS-HCC V28 mapping
RAF reference coefficient: —
Billable: Yes
Payment year: 2026

HCC Category Mapping

ESRDHCC 47, Disorders of Immunity

Not separately weighted

RxHCCHCC 99, Immune Disorders

Not separately weighted

These are source-labeled model coefficients, not member totals. A category may still be removed by hierarchy or model cleanup rules. Weights are not directly comparable across models: CMS-HCC V28 and V24 use Community, Non-Dual, Aged; ESRD uses the dialysis continuing-enrollee model; RxHCC is the Part D continuing-enrollee, non-low-income, aged weight (a larger scale than CMS-HCC). ACA/HHS has no single weight — it varies by metal level. Actual per-patient RAF contribution depends on member context, hierarchy and cleanup rules, interactions, and the model year used by the payer. V28 is the CMS-HCC model phased in over payment years 2024–2026; V24 remains available for historical review.

Work D82.2 in the Code Book — tabular path, V28 RAF reference, and MEAT checklist →

MEAT review for D82.2

For D82.2, confirm that the documentation supports the diagnosis and meets the applicable coding, encounter, program and payer requirements. MEAT (Monitor, Evaluate, Assess, or Treat) is a review mnemonic, not a universal CMS coding rule.

MMonitor: signs, symptoms, disease progression, or lab trending documented in the note
EEvaluate: test results, medication response, or physical findings reviewed by the provider
AAssess: explicit mention in the assessment or plan with acknowledgment of status
TTreat: medication, referral, procedure, therapy, or counseling tied to the diagnosis

Coder workflow notes

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What This Code Means

D82.2 is the ICD-10-CM diagnosis code for immunodeficiency with short-limbed stature. A rare genetic condition where the immune system is weakened and the person has unusually short limbs and stature. D82.2 sits in the ICD-10-CM chapter for diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (d50-d89), within the section covering certain disorders involving the immune mechanism (d80-d89).

D82.2 has no mapping under the CMS-HCC V28 or V24 community payment models. D82.2 has a separate mapping under the CMS-HCC ESRD model (HCC 47 (Disorders of Immunity)) and the Part D RxHCC model (HCC 99 (Immune Disorders)); the applicable result needs member context. D82.2 also appears in the HHS-HCC commercial risk model (HCC 074 (HHS-HCC 074 adult, RAF varies by metal level)), which is a commercial market model rather than a Medicare Advantage payment mapping. Do not assign V28 risk adjustment value from this page; verify the applicable model and payment year before using this code for risk adjustment.

This code represents a specific syndrome; document the short stature findings and immunodeficiency manifestations separately if needed.

HCC Buddy maintains structured V28 and V24 mapping, source-labeled coefficient references, and MEAT documentation criteria for D82.2 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.

Coding Tips

•This code represents a specific syndrome; document the short stature findings and immunodeficiency manifestations separately if needed
•Verify the diagnosis includes both immunodeficiency AND short-limbed stature to distinguish from other immunodeficiency disorders

Clinical Significance

Immunodeficiency with short-limbed stature, also known as cartilage-hair hypoplasia or short-limbed immune deficiency, is a rare autosomal recessive disorder caused by RMRP gene mutations. It combines skeletal dysplasia with variable immunodeficiency ranging from mild lymphopenia to severe combined immunodeficiency, and carries increased risk of malignancy, particularly non-Hodgkin lymphoma and skin cancers.

Documentation Requirements

✓Documentation must include genetic testing confirming RMRP mutation, skeletal survey showing metaphyseal dysplasia and short limbs, immunological assessment (lymphocyte subsets, immunoglobulin levels, vaccine responses), growth parameters, and cancer surveillance plan.
✓Document the specific severity of immune impairment and any associated features such as Hirschsprung disease or anemia.

Commonly Confused Codes

•D82.1 (DiGeorge syndrome, a different syndromic immunodeficiency), D82.0 (Wiskott-Aldrich syndrome with different associated features), D81.89 (other combined immunodeficiencies without skeletal features), Q77.0 (achondrogenesis for skeletal dysplasia without immunodeficiency).