C81.2A ICD-10-CM Code: Mixed cellularity Hodgkin lymphoma, in remission
C81.2A maps to CMS-HCC V28 21. A source-labeled RAF reference is available. Confirm the documented diagnosis and applicable coding requirements. MEAT criteria · RAF Calculator · HCC Buddy coding tools
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FY 2026 Apr update / Neoplasms (C00-D49) / Malignant neoplasms of lymphoid, hematopoietic and related tissue (C81-C96)
C81.2A
Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidanceMixed cellularity Hodgkin lymphoma, in remission
Mixed cellularity Hodgkin lymphoma that is currently in remission (no active disease detected).
Buddy Insight
Mixed cellularity Hodgkin lymphoma in remission indicates the patient has achieved a treatment response with no detectable active disease.
CMS-HCC V28
MappedHCC 21
Coefficient HCC 21: 0.671 (Community Non-Dual Aged (CNA))
CMS-HCC V24
HistoricalHistorical
Not used for CY2026 payment
ACA/HHS
MappedHCC 012
Code-level coefficient reference
ESRD/PACE
MappedHCC 10
Code-level coefficient reference
RXHCC
MappedHCC 21
Code-level coefficient reference
Code Book Path
Inclusion Terms
Official- Mixed cellularity classical Hodgkin lymphomaInherited from C81.2
Excludes 2
Official- Kaposi's sarcoma of lymph nodes (C46.3)Inherited from C81-C96
- secondary and unspecified neoplasm of lymph nodes (C77.-)Inherited from C81-C96
- secondary neoplasm of bone marrow (C79.52)Inherited from C81-C96
- secondary neoplasm of spleen (C78.89)Inherited from C81-C96
Related Codes
Includes
OfficialNo Includes notes are included in this display for C81.2A. Check the code and parent instructions in the Code Book.
Excludes 1
Official- personal history of Hodgkin lymphoma (Z85.71)Inherited from C81
Code First
OfficialNo Code First sequencing instructions are included in this display for C81.2A. Check the code and parent instructions in the Code Book.
Use Additional
OfficialNo Use Additional Code instructions are included in this display for C81.2A. Check the code and parent instructions in the Code Book.
Code Also
OfficialNo Code Also instructions are included in this display for C81.2A. Check the code and parent instructions in the Code Book.
Buddy Documentation Tip
MEAT Support
Audit Caution
Common Mistakes
Current with CMS: FY2026 ICD-10-CM Apr 1 update (effective Apr 1 – Sep 30, 2026) · CMS-HCC V28, 100% phased in for payment year 2026. FY2027 code set already staged for October 1, 2026. How HCC Buddy stays current →
Is C81.2A an HCC code?
Yes. C81.2A (Mixed cellularity Hodgkin lymphoma, in remission) maps to HCC 21, Lymphoma and Other Cancers under the CMS-HCC V28 risk adjustment model, with a source-labeled community non-dual aged reference coefficient of 0.671. Source-labeled code-level coefficients are references, not member totals. Actual contribution depends on complete member context, hierarchy and cleanup rules, interactions, and model year. HCC Buddy's RAF Calculator supports CMS-HCC V28 PY2026 and shows no score unless every required source and calculation check passes. It is billable for payment year 2026.
Coder answer: C81.2A is billable and maps to V28 HCC 21, Lymphoma and Other Cancers. Open it in the Code Book for the tabular path, RAF, and MEAT checklist.
- Code
- C81.2A
- Description
- Mixed cellularity Hodgkin lymphoma, in remission
- HCC (V28)
- HCC 21 — Lymphoma and Other Cancers
- RAF reference coefficient
- 0.671
- Billable
- Yes
- Payment year
- 2026
HCC Category Mapping
These are source-labeled model coefficients, not member totals. A category may still be removed by hierarchy or model cleanup rules. Weights are not directly comparable across models: CMS-HCC V28 and V24 use Community, Non-Dual, Aged; ESRD uses the dialysis continuing-enrollee model; RxHCC is the Part D continuing-enrollee, non-low-income, aged weight (a larger scale than CMS-HCC). ACA/HHS has no single weight — it varies by metal level. Actual per-patient RAF contribution depends on member context, hierarchy and cleanup rules, interactions, and the model year used by the payer. V28 is the CMS-HCC model phased in over payment years 2024–2026; V24 remains available for historical review.
Work C81.2A in the Code Book — tabular path, V28 RAF reference, and MEAT checklist →
MEAT review for C81.2A
For C81.2A, confirm that the documentation supports the diagnosis and meets the applicable coding, encounter, program and payer requirements. MEAT (Monitor, Evaluate, Assess, or Treat) is a review mnemonic, not a universal CMS coding rule.
- MMonitor: signs, symptoms, disease progression, or lab trending documented in the note
- EEvaluate: test results, medication response, or physical findings reviewed by the provider
- AAssess: explicit mention in the assessment or plan with acknowledgment of status
- TTreat: medication, referral, procedure, therapy, or counseling tied to the diagnosis
Coder workflow notes
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What This Code Means
C81.2A is the ICD-10-CM diagnosis code for mixed cellularity hodgkin lymphoma, in remission. Mixed cellularity Hodgkin lymphoma that is currently in remission (no active disease detected). C81.2A sits in the ICD-10-CM chapter for neoplasms (c00-d49), within the section covering malignant neoplasms of lymphoid, hematopoietic and related tissue (c81-c96).
Under the CMS-HCC V28 risk adjustment model, C81.2A maps to Lymphoma and Other Cancers (HCC 21) with a source-labeled community, non-dual, aged reference coefficient of 0.671. For CY2026 non-PACE Medicare Advantage, CMS uses 100% of the 2024 CMS-HCC model (V28). PACE uses a separate model blend. Source-labeled code-level coefficients are references, not member totals. Actual contribution depends on complete member context, hierarchy and cleanup rules, interactions, and model year. HCC Buddy's RAF Calculator supports CMS-HCC V28 PY2026 and shows no score unless every required source and calculation check passes.
Use this code only when remission status is explicitly documented. For C81.2A, confirm that the documentation supports the diagnosis and meets the applicable coding, encounter, program and payer requirements. MEAT (Monitor, Evaluate, Assess, or Treat) is a review mnemonic, not a universal CMS coding rule. When documentation is ambiguous, coders should issue a provider query rather than assume the highest-specificity variant.
HCC Buddy maintains structured V28 and V24 mapping, source-labeled coefficient references, and MEAT documentation criteria for C81.2A sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.
Coding Tips
- •Use this code only when remission status is explicitly documented
- •Remission status affects prognosis and follow-up care planning
Clinical Significance
Mixed cellularity Hodgkin lymphoma in remission indicates the patient has achieved a treatment response with no detectable active disease. Despite remission status, these patients require ongoing surveillance with periodic imaging and labs to detect relapse. This code remains HCC-relevant because the patient's cancer history continues to drive resource utilization for monitoring, management of treatment side effects, and survivorship care.
Documentation Requirements
- ✓Explicit provider statement of remission status (complete remission, partial remission, or unspecified remission)
- ✓Supporting evidence such as PET/CT showing no metabolically active disease
- ✓History of pathology-confirmed mixed cellularity Hodgkin lymphoma
- ✓Documentation of ongoing surveillance plan or survivorship care
- ✓Date of last treatment completion and duration of remission when available
Commonly Confused Codes
- •C81.20-C81.29: Active mixed cellularity Hodgkin lymphoma by site: use the site-specific code when disease is still active; use C81.2A only when remission is explicitly documented
- •Z85.71: Personal history of Hodgkin lymphoma: use Z85.71 only when the lymphoma is considered cured and no longer under active oncologic surveillance; C81.2A is appropriate during active monitoring in remission
- •C81.2A vs. Z85.71: The key distinction is whether the oncologist considers the disease in remission (still trackable) versus cured (historical only)